| Literature DB >> 1821247 |
G D Tollefson1, J Montague-Clouse, S P Lancaster.
Abstract
Adverse drug reactions among elderly patients pose a significant clinical problem. The authors used a serum radioreceptor assay [RRA] to quantify drug-induced muscarinic blockade in 34 randomly selected nursing home residents. A random intervention group and the nonintervention control subjects were then retested 4 weeks later. The reduction of serum antimuscarinic activity (as determined by RRA) did relate to changes on several measures of cognitive function. A calculated "antimuscarinic index" lost significance with the RRA following intervention and may have overestimated the impact of a dosage reduction.Entities:
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Year: 1991 PMID： 1821247 DOI： 10.1176/jnp.3.3.314
Source DB: PubMed Journal: J Neuropsychiatry Clin Neurosci ISSN： 0895-0172 Impact factor: 2.198