Literature DB >> 182118

Inhibition of glycolytic enzymes by 2-phosphotartronate.

M K Thomas, T G Spring.   

Abstract

2-Phosphotartronate has been synthesized by permanganate oxidation of glycerol 2-phosphate and has been tested as an inhibitor of five glycolytic enzymes that bind phosphoglycerate or phosphoglycollate. Competitive inhibition of rabbit muscle phosphoglycerate mutase, enolase and pyruvate kinase was observed. Triose phosphate isomerase and 3-phosphoglycerate kinase were not inhibited.

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Year:  1976        PMID： 182118      PMCID： PMC1172646          DOI： 10.1042/bj1530741

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

1.  Separation of the phosphoric esters on the filter paper chromatogram.

Authors:  C S HANES; F A ISHERWOOD
Journal:  Nature       Date:  1949-12-31       Impact factor: 49.962

2.  A direct spectrophotometric assay for pyruvate kinase.

Authors:  N G Pon; R J Bondar
Journal:  Anal Biochem       Date:  1967-05       Impact factor: 3.365

3.  The effect of normal red cell constituents on the activities of red cell enzymes.

Authors:  S K Srivastava; E Beutler
Journal:  Arch Biochem Biophys       Date:  1972-01       Impact factor: 4.013

4.  Formation of an active phosphoenzyme by diphosphoglycerate-dependent phosphoglyceromutases from muscle, kidney and yeast.

Authors:  H G Britton; J Carreras; S Grisolia
Journal:  Biochim Biophys Acta       Date:  1972-12-07

5.  Studies on two high-affinity enolase inhibitors. Chemical characterization.

Authors:  T G Spring; F Wold
Journal:  Biochemistry       Date:  1971-12-07       Impact factor: 3.162

6.  Isolation and characterization of rabbit muscle triose phosphate isomerase.

Authors:  I L Norton; P Pfuderer; C D Stringer; F C Hartman
Journal:  Biochemistry       Date:  1970-12-08       Impact factor: 3.162

7.  Stereoselective interactions of phosphoenolpyruvate analogues with phosphoenolpyruvate-utilizing enzymes.

Authors:  T Nowak; A S Mildvan
Journal:  J Biol Chem       Date:  1970-11-25       Impact factor: 5.157

8.  The isolation and crystallization of yeast and rabbit liver triose phosphate isomerase and a comparative characterization with the rabbit muscle enzyme.

Authors:  W K Krietsch; P G Pentchev; H Klingenbürg; T Hofstätter; T Bücher
Journal:  Eur J Biochem       Date:  1970-06

9.  Nuclear magnetic resonance studies of selectively hindered internal motion of substrate analogs at the active site of pyruvate kinase.

Authors:  T Nowak; A S Mildvan
Journal:  Biochemistry       Date:  1972-07-18       Impact factor: 3.162

10.  Studies on two high-affinity enolase inhibitors. Reaction with enolases.

Authors:  T G Spring; F Wold
Journal:  Biochemistry       Date:  1971-12-07       Impact factor: 3.162
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