BACKGROUND: Four cardiac hormones i.e. atrial natriuretic peptide (ANP), vessel dilator, long acting natriuretic peptide (LANP) and kaliuretic peptide have anticancer effects in vitro. MATERIALS AND METHODS: These four cardiac hormones were infused subcutaneously for 28 days with weekly fresh hormones at 3 nM min(-1) kg(-1) body weight in athymic mice bearing human breast adenocarcinomas. RESULTS: Vessel dilator, LANP, kaliuretic peptide and ANP eliminated 67%, 50%, 67% and 33% of the HTB-132 human breast adenocarcinomas. LANP eliminated 100% and vessel dilator 1/3 of CRL-2327 breast adenocarcinomas. There was no recurrence of the breast cancers in the primary site and no metastasis except in the ANP-treated group in one year post-treatment. The natriuretic peptide receptors-A and -C were decreased 50% and 31%, respectively, in metastatic versus primary ANP-treated breast adenocarcinomas. CONCLUSION: Four cardiac hormones eliminate up to two-thirds of human breast adenocarcinomas in athymic mice.
BACKGROUND: Four cardiac hormones i.e. atrial natriuretic peptide (ANP), vessel dilator, long acting natriuretic peptide (LANP) and kaliuretic peptide have anticancer effects in vitro. MATERIALS AND METHODS: These four cardiac hormones were infused subcutaneously for 28 days with weekly fresh hormones at 3 nM min(-1) kg(-1) body weight in athymic mice bearing humanbreast adenocarcinomas. RESULTS: Vessel dilator, LANP, kaliuretic peptide and ANP eliminated 67%, 50%, 67% and 33% of the HTB-132 humanbreast adenocarcinomas. LANP eliminated 100% and vessel dilator 1/3 of CRL-2327 breast adenocarcinomas. There was no recurrence of the breast cancers in the primary site and no metastasis except in the ANP-treated group in one year post-treatment. The natriuretic peptide receptors-A and -C were decreased 50% and 31%, respectively, in metastatic versus primary ANP-treated breast adenocarcinomas. CONCLUSION: Four cardiac hormones eliminate up to two-thirds of humanbreast adenocarcinomas in athymic mice.
Authors: Meghan L Lane; Chelsea D Frost; Jennifer P Nguyen; William P Skelton; Michelle Skelton; David L Vesely Journal: Mol Cell Biochem Date: 2012-09-11 Impact factor: 3.396
Authors: Maha E Houssen; Hayam F Ghazy; Kamel Farag; Mona Abo Bakr El-Hussiny; Mohamed A El Ghaffar; Sahar Alsayed Mohamed Alsayed; Omar Farouk Journal: Contemp Oncol (Pozn) Date: 2017-03-22