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Literature DB >> 18208397

The MCM helicase: linking checkpoints to the replication fork.

Abstract

The MCM (minichromosome maintenance) complex is a helicase which is essential for DNA replication. Recent results suggest that the MCM helicase is important for replication fork integrity, and may function as a target of the replication checkpoint. Interactions between MCM proteins, checkpoint kinases, and repair and recovery proteins suggest that MCMs are proximal effectors of replication fork stability in the cell and are likely to play an important role in maintaining genome integrity.

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Year: 2008 PMID： 18208397 DOI： 10.1042/BST0360114

Source DB: PubMed Journal: Biochem Soc Trans ISSN： 0300-5127 Impact factor: 5.407

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Cited

20 in total

1. DNA repair and replication fork helicases are differentially affected by alkyl phosphotriester lesion.

Authors: Avvaru N Suhasini; Joshua A Sommers; Stephen Yu; Yuliang Wu; Ting Xu; Zvi Kelman; Daniel L Kaplan; Robert M Brosh
Journal: J Biol Chem Date: 2012-04-12 Impact factor: 5.157

Review 2. Insights into the MCM functional mechanism: lessons learned from the archaeal MCM complex.

Authors: Aaron S Brewster; Xiaojiang S Chen
Journal: Crit Rev Biochem Mol Biol Date: 2010-06 Impact factor: 8.250

3. Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions.

Authors: Jianyin Long; Yin Wang; Wenjian Wang; Benny H J Chang; Farhad R Danesh
Journal: J Biol Chem Date: 2010-05-25 Impact factor: 5.157

4. Minichromosome maintenance protein 7 as a potential prognostic factor for progression-free survival in high-grade serous carcinomas of the ovary.

Authors: Takayo Ota; Amy C Clayton; Douglas M Minot; Viji Shridhar; Lynn C Hartmann; C Blake Gilks; Jeremy R Chien
Journal: Mod Pathol Date: 2010-11-12 Impact factor: 7.842

The MCM helicase: linking checkpoints to the replication fork.

1. DNA repair and replication fork helicases are differentially affected by alkyl phosphotriester lesion.

Review 2. Insights into the MCM functional mechanism: lessons learned from the archaeal MCM complex.

3. Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions.

4. Minichromosome maintenance protein 7 as a potential prognostic factor for progression-free survival in high-grade serous carcinomas of the ovary.

5. Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells.

6. A novel proteomics approach for the discovery of chromatin-associated protein networks.

7. Smc5/6 maintains stalled replication forks in a recombination-competent conformation.

Review 8. The Mcm complex: unwinding the mechanism of a replicative helicase.

9. Functional cooperation between FACT and MCM is coordinated with cell cycle and differential complex formation.

10. Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes.