UNLABELLED: This study aims to investigate the usefulness of F-18 FDG PET/CT in differentiated thyroid cancer (DTC) with elevated serum thyroglobulin (Tg) but negative iodine-123 (I-123) scan. METHODS: Twenty patients with histopathologically proven DTC, negative diagnostic I-123 scan, and elevated serum Tg levels were prospectively submitted to F-18 FDG PET/CT evaluation. The histopathologic findings consisted of 19 papillary thyroid cancers, 1 follicular thyroid cancer. RESULTS: F-18 FDG PET/CT identified lesions in 18 out of 20 patients, giving a sensitivity of 90%. Thirteen of the 18 patients revealed limited loco-regional disease. Remaining 5 patients showed distant metastases, consisting of 4 patients with lung metastases and 1 patient with bone metastasis. Two patients revealed negative F-18 FDG PET/CT findings. CONCLUSION: F-18 FDG PET/CT is suitable for the detection and precise localization of loco-regional recurrences and distant metastases of DTC in patients with elevated serum Tg but negative I-123 whole body scan.
UNLABELLED: This study aims to investigate the usefulness of F-18 FDG PET/CT in differentiated thyroid cancer (DTC) with elevated serum thyroglobulin (Tg) but negative iodine-123 (I-123) scan. METHODS: Twenty patients with histopathologically proven DTC, negative diagnostic I-123 scan, and elevated serum Tg levels were prospectively submitted to F-18 FDG PET/CT evaluation. The histopathologic findings consisted of 19 papillary thyroid cancers, 1 follicular thyroid cancer. RESULTS: F-18 FDG PET/CT identified lesions in 18 out of 20 patients, giving a sensitivity of 90%. Thirteen of the 18 patients revealed limited loco-regional disease. Remaining 5 patients showed distant metastases, consisting of 4 patients with lung metastases and 1 patient with bone metastasis. Two patients revealed negative F-18 FDG PET/CT findings. CONCLUSION: F-18 FDG PET/CT is suitable for the detection and precise localization of loco-regional recurrences and distant metastases of DTC in patients with elevated serum Tg but negative I-123 whole body scan.
Authors: Michael W Yeh; Andrew J Bauer; Victor A Bernet; Robert L Ferris; Laurie A Loevner; Susan J Mandel; Lisa A Orloff; Gregory W Randolph; David L Steward Journal: Thyroid Date: 2015-01 Impact factor: 6.568
Authors: Johann-Martin Hempel; Roman Kloeckner; Sandra Krick; Daniel Pinto Dos Santos; Simin Schadmand-Fischer; Patrick Boeßert; Sotirios Bisdas; Matthias M Weber; Christian Fottner; Thomas J Musholt; Mathias Schreckenberger; Matthias Miederer Journal: Cancer Imaging Date: 2016-11-03 Impact factor: 3.909
Authors: Jennifer M J Schreinemakers; Menno R Vriens; Nuria Munoz-Perez; Marlon A Guerrero; Insoo Suh; Inne H M Borel Rinkes; Jessica Gosnell; Wen T Shen; Orlo H Clark; Quan-Yang Duh Journal: World J Surg Oncol Date: 2012-09-17 Impact factor: 2.754