| Literature DB >> 18207394 |
Chen Chen1, Brian Dyck, Beth A Fleck, Alan C Foster, Jonathan Grey, Florence Jovic, Michael Mesleh, Kasey Phan, Junko Tamiya, Troy Vickers, Mingzhu Zhang.
Abstract
Derivatives of milnacipran were synthesized and studied as monoamine transporter inhibitors. Potent analogs were discovered at NET (9k) and at both NET and SERT (9s and 9u). A pharmacophore model was established based on the conformational analysis of milnacipran in aqueous solution using NMR techniques and was consistent with the SAR results.Entities:
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Year: 2008 PMID： 18207394 DOI： 10.1016/j.bmcl.2008.01.011
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823