| Literature DB >> 18207393 |
Brijesh Kumar Srivastava1, Rina Soni, Amit Joharapurkar, Kalapatapu V V M Sairam, Jayendra Z Patel, Amitgiri Goswami, Sandeep A Shedage, Sidhartha S Kar, Rahul P Salunke, Shivaji B Gugale, Amol Dhawas, Pravin Kadam, Bhupendra Mishra, Nisha Sadhwani, Vishal B Unadkat, Prasenjit Mitra, Mukul R Jain, Pankaj R Patel.
Abstract
Design, synthesis and conformational analysis of few imidazole and oxazole as bioisosters of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N'-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) 2 is reported. Computer assisted conformational analysis gave a direct clue for the loss of CB1 antagonistic activity of the ligands without a fine docking simulation for the homology model.Entities:
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Year: 2007 PMID： 18207393 DOI： 10.1016/j.bmcl.2007.12.036
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823