Literature DB >> 18207351

Early maturation of GABAergic synapses in mouse retinal ganglion cells.

Thomas Unsoeld1, Alicja M Stradomska, Rui Wang, Fritz G Rathjen, Rene Jüttner.   

Abstract

This study was aimed to characterize the earliest phases of synapse development in mouse retinal ganglion cells (RGCs) by recording spontaneous postsynaptic currents (PSCs). First PSCs were detected at embryonic day 17 and completely suppressed by bicuculline, demonstrating their GABAergic nature. Starting from postnatal day 3 a small fraction of RGCs had rapidly decaying, most likely glutamatergic currents. The present results suggest that functional GABAergic synapses with RGCs appear before birth and that GABAergic synaptic transmission precedes that of glutamate in the retina. In this early period GABA acts in a depolarizing manner and takes over an excitatory function.

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Year:  2007        PMID： 18207351     DOI： 10.1016/j.ijdevneu.2007.12.001

Source DB:  PubMed          Journal:  Int J Dev Neurosci        ISSN： 0736-5748            Impact factor:   2.457


  7 in total

1.  Repetitive magnetic stimulation of human-derived neuron-like cells activates cAMP-CREB pathway.

Authors:  Julian Hellmann; Rene Jüttner; Clarisse Roth; Malek Bajbouj; Imke Kirste; Isabella Heuser; Karen Gertz; Matthias Endres; Golo Kronenberg
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2011-05-12       Impact factor: 5.270

Review 2.  Functional architecture of the retina: development and disease.

Authors:  Mrinalini Hoon; Haruhisa Okawa; Luca Della Santina; Rachel O L Wong
Journal:  Prog Retin Eye Res       Date:  2014-06-28       Impact factor: 21.198

3.  Plasmalemmal and vesicular gamma-aminobutyric acid transporter expression in the developing mouse retina.

Authors:  Chenying Guo; Salvatore L Stella; Arlene A Hirano; Nicholas C Brecha
Journal:  J Comp Neurol       Date:  2009-01-01       Impact factor: 3.215

4.  Functional hallmarks of GABAergic synapse maturation and the diverse roles of neurotrophins.

Authors:  Rosemarie Grantyn; Christian Henneberger; René Jüttner; Jochen C Meier; Sergei Kirischuk
Journal:  Front Cell Neurosci       Date:  2011-07-04       Impact factor: 5.505

5.  Coordinated increase in inhibitory and excitatory synapses onto retinal ganglion cells during development.

Authors:  Florentina Soto; Adam Bleckert; Renate Lewis; Yunhee Kang; Daniel Kerschensteiner; Ann Marie Craig; Rachel O L Wong
Journal:  Neural Dev       Date:  2011-08-24       Impact factor: 3.842

6.  Spatial relationships between GABAergic and glutamatergic synapses on the dendrites of distinct types of mouse retinal ganglion cells across development.

Authors:  Adam Bleckert; Edward D Parker; Yunhee Kang; Raika Pancaroglu; Florentina Soto; Renate Lewis; Ann Marie Craig; Rachel O L Wong
Journal:  PLoS One       Date:  2013-07-26       Impact factor: 3.240

7.  The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in mice.

Authors:  Hanna Langhorst; René Jüttner; Dieter Groneberg; Azadeh Mohtashamdolatshahi; Laura Pelz; Bettina Purfürst; Kai M Schmidt-Ott; Andreas Friebe; Fritz G Rathjen
Journal:  Dis Model Mech       Date:  2018-02-22       Impact factor: 5.758
  7 in total

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