Literature DB >> 18207323

Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats.

Randy L Hunter1, Dong-Young Choi, Stuart A Ross, Guoying Bing.   

Abstract

We created an inflammation-induced Parkinson's disease model, where microglia activation leads to oxidative stress, mitochondrial dysfunction, and dopaminergic neurodegeneration in the substantia nigra. Pioglitazone, an agonist of peroxisome proliferator activated receptor-gamma (PPAR-gamma), can prevent these deficits and protect dopaminergic neurons. To continue exploring the effects of pioglitazone in this model we focused on the expression of PPAR-gamma, uncoupling protein 2 (UCP2), and mitoNEET. We report that intrastriatal lipopolysaccharide (LPS) increases striatal PPAR-gamma, UCP2, and mitoNEET expression, and pioglitazone attenuates these LPS-induced changes.

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Year:  2008        PMID： 18207323      PMCID： PMC2699576          DOI： 10.1016/j.neulet.2007.12.019

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  30 in total

Review 1.  Inflammation in Parkinson's disease.

Authors:  P L McGeer; K Yasojima; E G McGeer
Journal:  Adv Neurol       Date:  2001

2.  Induction of UCP2 gene expression by LPS: a potential mechanism for increased thermogenesis during infection.

Authors:  R Faggioni; J Shigenaga; A Moser; K R Feingold; C Grunfeld
Journal:  Biochem Biophys Res Commun       Date:  1998-03-06       Impact factor: 3.575

3.  MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity.

Authors:  Sandra E Wiley; Anne N Murphy; Stuart A Ross; Peter van der Geer; Jack E Dixon
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-21       Impact factor: 11.205

Review 4.  Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?

Authors:  D L Feinstein; A Spagnolo; C Akar; G Weinberg; P Murphy; V Gavrilyuk; C Dello Russo
Journal:  Biochem Pharmacol       Date:  2005-07-15       Impact factor: 5.858

5.  Superoxide activates mitochondrial uncoupling proteins.

Authors:  Karim S Echtay; Damien Roussel; Julie St-Pierre; Mika B Jekabsons; Susana Cadenas; Jeff A Stuart; James A Harper; Stephen J Roebuck; Alastair Morrison; Susan Pickering; John C Clapham; Martin D Brand
Journal:  Nature       Date:  2002-01-03       Impact factor: 49.962

6.  Intrapallidal lipopolysaccharide injection increases iron and ferritin levels in glia of the rat substantia nigra and induces locomotor deficits.

Authors:  J Zhang; D M Stanton; X V Nguyen; M Liu; Z Zhang; D Gash; G Bing
Journal:  Neuroscience       Date:  2005-09-13       Impact factor: 3.590

Review 7.  The role of PPARs in inflammation and immunity.

Authors:  Robert B Clark
Journal:  J Leukoc Biol       Date:  2002-03       Impact factor: 4.962

8.  Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease.

Authors:  Zane B Andrews; Balazs Horvath; Colin J Barnstable; John Elsworth; John Elseworth; Lichuan Yang; M Flynt Beal; Robert H Roth; Russell T Matthews; Tamas L Horvath
Journal:  J Neurosci       Date:  2005-01-05       Impact factor: 6.167

9.  Attenuation of colonic inflammation by PPARgamma in intestinal epithelial cells: effect on Toll-like receptor pathway.

Authors:  Chang Soo Eun; Dong Soo Han; Seung Hyun Lee; Chang Hee Paik; Yong Woo Chung; Jin Lee; Joon Soo Hahm
Journal:  Dig Dis Sci       Date:  2006-04       Impact factor: 3.199

Review 10.  Emerging roles of PPARs in inflammation and immunity.

Authors:  Raymond A Daynes; Dallas C Jones
Journal:  Nat Rev Immunol       Date:  2002-10       Impact factor: 53.106
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  28 in total

1.  Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons.

Authors:  Tristano Pancani; Jeremiah T Phelps; James L Searcy; Michael W Kilgore; Kuey-Chu Chen; Nada M Porter; Olivier Thibault
Journal:  J Neurochem       Date:  2009-05-11       Impact factor: 5.372

2.  Novel ligands that target the mitochondrial membrane protein mitoNEET.

Authors:  Robert M Bieganski; Martin L Yarmush
Journal:  J Mol Graph Model       Date:  2011-04-13       Impact factor: 2.518

Review 3.  Neuroprotective mechanisms of peroxisome proliferator-activated receptor agonists in Alzheimer's disease.

Authors:  Rupinder K Sodhi; Nirmal Singh; Amteshwar S Jaggi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2011-05-24       Impact factor: 3.000

4.  Quantitative Proteomics of Presynaptic Mitochondria Reveal an Overexpression and Biological Relevance of Neuronal MitoNEET in Postnatal Brain Development.

Authors:  Kelly L Stauch; Lance M Villeneuve; Steven Totusek; Benjamin Lamberty; Pawel Ciborowski; Howard S Fox
Journal:  Dev Neurobiol       Date:  2019-05-09       Impact factor: 3.964

5.  Differential Effects of LPS and 6-OHDA on Microglia's Morphology in Rats: Implications for Inflammatory Model of Parkinson's Disease.

Authors:  Irving Parra; Isabel Martínez; Gabriel Ramírez-García; Yousef Tizabi; Liliana Mendieta
Journal:  Neurotox Res       Date:  2019-09-02       Impact factor: 3.911

6.  Inflammation alters AMPA-stimulated calcium responses in dorsal striatal D2 but not D1 spiny projection neurons.

Authors:  Carissa D Winland; Nora Welsh; Alberto Sepulveda-Rodriguez; Stefano Vicini; Kathleen A Maguire-Zeiss
Journal:  Eur J Neurosci       Date:  2017-10-10       Impact factor: 3.386

7.  Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury.

Authors:  Andrew Sauerbeck; Jianxin Gao; Ryan Readnower; Mei Liu; James R Pauly; Guoying Bing; Patrick G Sullivan
Journal:  Exp Neurol       Date:  2010-10-20       Impact factor: 5.330

8.  MitoNEET Deficiency Alleviates Experimental Alcoholic Steatohepatitis in Mice by Stimulating Endocrine Adiponectin-Fgf15 Axis.

Authors:  Xudong Hu; Alvin Jogasuria; Jiayou Wang; Chunki Kim; Yoonhee Han; Hong Shen; Jiashin Wu; Min You
Journal:  J Biol Chem       Date:  2016-08-29       Impact factor: 5.157

9.  Effects of long-term pioglitazone treatment on peripheral and central markers of aging.

Authors:  Eric M Blalock; Jeremiah T Phelps; Tristano Pancani; James L Searcy; Katie L Anderson; John C Gant; Jelena Popovic; Margarita G Avdiushko; Don A Cohen; Kuey-Chu Chen; Nada M Porter; Olivier Thibault
Journal:  PLoS One       Date:  2010-04-29       Impact factor: 3.240

Review 10.  Reassessment of Pioglitazone for Alzheimer's Disease.

Authors:  Ann M Saunders; Daniel K Burns; William Kirby Gottschalk
Journal:  Front Neurosci       Date:  2021-06-16       Impact factor: 4.677
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