| Literature DB >> 18207215 |
Daniel Gibbs1, Zhenglin Yang, Ryan Constantine, Xiang Ma, Nicola J Camp, Xian Yang, Hayou Chen, Adam Jorgenson, Vincent Hau, Andrew Dewan, Jiexi Zeng, Jennifer Harmon, Jeanette Buehler, John M Brand, Josephine Hoh, D Joshua Cameron, Manjusha Dixit, Zongzhong Tong, Kang Zhang.
Abstract
Age-related macular degeneration (AMD) is a complex disorder with genetic and environmental influences. The genetic influences affecting AMD are not well understood and few genes have been consistently implicated and replicated for this disease. A polymorphism (rs11200638) in a transcription factor binding site of the HTRA1 gene has been described, in previous reports, as being most significantly associated with AMD. In this paper, we investigate haplotype association and individual polymorphic association by genotyping additional variants in the AMD risk-associated region of chromosome 10q26. We demonstrate that rs11200638 in the promoter region and rs2293870 in exon 1 of HTRA1, are among the most significantly associated variants for advanced forms of AMD.Entities:
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Year: 2008 PMID： 18207215 DOI： 10.1016/j.visres.2007.10.022
Source DB: PubMed Journal: Vision Res ISSN： 0042-6989 Impact factor: 1.886