Literature DB >> 1820580

Glutathione metabolism and its role in hepatotoxicity.

L D DeLeve1, N Kaplowitz.   

Abstract

Glutathione (GSH) fulfills several essential functions: Detoxification of free radicals and toxic oxygen radicals, thiol-disulfide exchange and storage and transfer of cysteine. GSH is present in all mammalian cells, but may be especially important for organs with intense exposure to exogenous toxins such as the liver, kidney, lung and intestine. Within the cell mitochondrial GSH is the main defense against physiological oxidant stress generated by cellular respiration and may be a critical target for toxic oxygen and electrophilic metabolites. Glutathione homeostasis is a highly complex process, which is predominantly regulated by the liver, lung and kidney.

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Year:  1991        PMID： 1820580     DOI： 10.1016/0163-7258(91)90029-l

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  73 in total

Review 1.  Specific effects of reactive thiol drugs on mitochondrial bioenergetics.

Authors:  Iseli L Nantes; Tiago Rodrigues; Antonio C F Caires; Rodrigo L O R Cunha; Felipe S Pessoto; César H Yokomizo; Juliana C Araujo-Chaves; Priscila A Faria; Debora P Santana; Carolina G dos Santos
Journal:  J Bioenerg Biomembr       Date:  2011-02       Impact factor: 2.945

2.  Design of an in vivo cleavable disulfide linker in recombinant fusion proteins.

Authors:  Xiaoying Chen; Yun Bai; Jennica L Zaro; Wei-Chiang Shen
Journal:  Biotechniques       Date:  2010-07       Impact factor: 1.993

3.  Oxidative stress and antioxidant responses of liver and kidney tissue after implantation of titanium or titanium oxide coated plate in rat tibiae.

Authors:  Nahla S El-Shenawy; Q Mohsen; Sahar A Fadl-allah
Journal:  J Mater Sci Mater Med       Date:  2012-05-17       Impact factor: 3.896

Review 4.  Oxidative stress, unfolded protein response, and apoptosis in developmental toxicity.

Authors:  Allison Kupsco; Daniel Schlenk
Journal:  Int Rev Cell Mol Biol       Date:  2015-03-11       Impact factor: 6.813

5.  Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice.

Authors:  James P Luyendyk; Glenn H Cantor; Daniel Kirchhofer; Nigel Mackman; Bryan L Copple; Ruipeng Wang
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2009-01-29       Impact factor: 4.052

6.  Bile acid supplementation improves established liver steatosis in obese mice independently of glucagon-like peptide-1 secretion.

Authors:  Pablo Quintero; Margarita Pizarro; Nancy Solís; Juan Pablo Arab; Oslando Padilla; Arnoldo Riquelme; Marco Arrese
Journal:  J Physiol Biochem       Date:  2014-05-10       Impact factor: 4.158

Review 7.  Bioreducible polycations as shuttles for therapeutic nucleic acid and protein transfection.

Authors:  Philipp M Klein; Ernst Wagner
Journal:  Antioxid Redox Signal       Date:  2014-01-08       Impact factor: 8.401

8.  Glutathione deficiency down-regulates hepatic lipogenesis in rats.

Authors:  Corinna Brandsch; Tobias Schmidt; Diana Behn; Kristin Weisse; Andreas S Mueller; Gabriele I Stangl
Journal:  Lipids Health Dis       Date:  2010-05-19       Impact factor: 3.876

9.  Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB.

Authors:  Alvin J L Chia; Christopher E Goldring; Neil R Kitteringham; Shi Quan Wong; Paul Morgan; B Kevin Park
Journal:  Biochem Pharmacol       Date:  2010-04-21       Impact factor: 5.858

10.  Gene expression profiles of colonic mucosa in healthy young adult and senior dogs.

Authors:  Dong Yong Kil; Brittany M Vester Boler; Carolyn J Apanavicius; Lawrence B Schook; Kelly S Swanson
Journal:  PLoS One       Date:  2010-09-22       Impact factor: 3.240
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