Literature DB >> 18205296

Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors.

Benoît M R Liénard1, Rebekka Hüting, Patricia Lassaux, Moreno Galleni, Jean-Marie Frère, Christopher J Schofield.   

Abstract

The use of protein ESI mass spectrometry under non-denaturing conditions to analyze a dynamic combinatorial library of thiols/disulfides with the BcII metallo-beta-lactamase enabled the rapid identification of an inhibitor with a K(i) of < 1 microM. The study exemplifies the utility of protein-MS for screening dynamic mixtures of potential enzyme-inhibitors.

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Year:  2008        PMID： 18205296     DOI： 10.1021/jm070866g

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  12 in total

Review 1.  Fragment-based inhibitor discovery against β-lactamase.

Authors:  Derek A Nichols; Adam R Renslo; Yu Chen
Journal:  Future Med Chem       Date:  2014-03       Impact factor: 3.808

Review 2.  Current challenges in antimicrobial chemotherapy: focus on ß-lactamase inhibition.

Authors:  Carine Bebrone; Patricia Lassaux; Lionel Vercheval; Jean-Sébastien Sohier; Adrien Jehaes; Eric Sauvage; Moreno Galleni
Journal:  Drugs       Date:  2010-04-16       Impact factor: 9.546

Review 3.  The Continuing Challenge of Metallo-β-Lactamase Inhibition: Mechanism Matters.

Authors:  Lin-Cheng Ju; Zishuo Cheng; Walter Fast; Robert A Bonomo; Michael W Crowder
Journal:  Trends Pharmacol Sci       Date:  2018-04-18       Impact factor: 14.819

4.  Dynamic combinatorial selection of molecules capable of inhibiting the (CUG) repeat RNA-MBNL1 interaction in vitro: discovery of lead compounds targeting myotonic dystrophy (DM1).

Authors:  Peter C Gareiss; Krzysztof Sobczak; Brian R McNaughton; Prakash B Palde; Charles A Thornton; Benjamin L Miller
Journal:  J Am Chem Soc       Date:  2008-12-03       Impact factor: 15.419

5.  Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase.

Authors:  Mariano M González; Magda Kosmopoulou; Maria F Mojica; Valerie Castillo; Philip Hinchliffe; Ilaria Pettinati; Jürgen Brem; Christopher J Schofield; Graciela Mahler; Robert A Bonomo; Leticia I Llarrull; James Spencer; Alejandro J Vila
Journal:  ACS Infect Dis       Date:  2015-07-20       Impact factor: 5.084

6.  A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry.

Authors:  Duncan E Scott; Gwen J Dawes; Michiyo Ando; Chris Abell; Alessio Ciulli
Journal:  Chembiochem       Date:  2009-11-23       Impact factor: 3.164

Review 7.  Three decades of beta-lactamase inhibitors.

Authors:  Sarah M Drawz; Robert A Bonomo
Journal:  Clin Microbiol Rev       Date:  2010-01       Impact factor: 26.132

8.  An Update on the Status of Potent Inhibitors of Metallo-β-Lactamases.

Authors:  Nazar Ul Islam
Journal:  Sci Pharm       Date:  2013-03-28

9.  Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

Authors:  Nathan R Rose; Esther C Y Woon; Guy L Kingham; Oliver N F King; Jasmin Mecinović; Ian J Clifton; Stanley S Ng; Jobina Talib-Hardy; Udo Oppermann; Michael A McDonough; Christopher J Schofield
Journal:  J Med Chem       Date:  2010-02-25       Impact factor: 7.446

10.  Assay platform for clinically relevant metallo-β-lactamases.

Authors:  Sander S van Berkel; Jürgen Brem; Anna M Rydzik; Ramya Salimraj; Ricky Cain; Anil Verma; Raymond J Owens; Colin W G Fishwick; James Spencer; Christopher J Schofield
Journal:  J Med Chem       Date:  2013-08-16       Impact factor: 7.446
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