BACKGROUND: An accumulating body of evidence suggests that there is an inverse relationship between the intake of folate (a water-soluble B-vitamin) and the risk of developing breast cancer. Individual variation in the genes involved in the transport of folate, or its metabolism, may affect risk, or may modify the association between folate and breast cancer risk. METHODS: We performed a case-control study to evaluate the association between common polymorphisms in six folate-related genes and the risk of breast cancer in 1,009 breast cancer patients and 907 healthy controls. Study subjects were genotyped for eight single nucleotide polymorphisms (SNPs) in these six genes. RESULTS: We observed no association between the MTHFR, RFC, MS and MTRR genotypes and the risk of breast cancer. CONCLUSION: These data do not support the hypothesis that genetic variation in genes involved in the metabolism of folate are implicated in the etiology of breast cancer.
BACKGROUND: An accumulating body of evidence suggests that there is an inverse relationship between the intake of folate (a water-soluble B-vitamin) and the risk of developing breast cancer. Individual variation in the genes involved in the transport of folate, or its metabolism, may affect risk, or may modify the association between folate and breast cancer risk. METHODS: We performed a case-control study to evaluate the association between common polymorphisms in six folate-related genes and the risk of breast cancer in 1,009 breast cancerpatients and 907 healthy controls. Study subjects were genotyped for eight single nucleotide polymorphisms (SNPs) in these six genes. RESULTS: We observed no association between the MTHFR, RFC, MS and MTRR genotypes and the risk of breast cancer. CONCLUSION: These data do not support the hypothesis that genetic variation in genes involved in the metabolism of folate are implicated in the etiology of breast cancer.
Authors: Rita de Cássia Carvalho Barbosa; Débora Costa Menezes; Thiago Fernando Vasconcelos Freire; Diogo Campos Sales; Victor Hugo Medeiros Alencar; Silvia Helena Barem Rabenhorst Journal: Mol Biol Rep Date: 2011-12-02 Impact factor: 2.316
Authors: Adana A Llanos; Ramona G Dumitrescu; Theodore M Brasky; Zhenhua Liu; Joel B Mason; Catalin Marian; Kepher H Makambi; Scott L Spear; Bhaskar V S Kallakury; Jo L Freudenheim; Peter G Shields Journal: Carcinogenesis Date: 2014-10-24 Impact factor: 4.944
Authors: Zhihong Gong; Song Yao; Gary Zirpoli; Ting-Yuan David Cheng; Michelle Roberts; Thaer Khoury; Gregory Ciupak; Warren Davis; Karen Pawlish; Lina Jandorf; Dana H Bovbjerg; Elisa V Bandera; Christine B Ambrosone Journal: Int J Cancer Date: 2015-01-29 Impact factor: 7.396