Literature DB >> 18204420

The cysteinyl leukotrienes: where do they come from? What are they? Where are they going?

K Frank Austen1.   

Abstract

Cysteinyl leukotrienes are established mediators of bronchial asthma and have agonist roles analogous to those of histamine in allergic rhinitis. We now know that the substance originally termed slow-reacting substance of anaphylaxis was composed of three cysteinyl leukotrienes that act in the inflammatory response via receptors on smooth muscle and on bone marrow-derived inflammatory cells. K. Frank Austen describes the work culminating in the identification, biosynthesis and functional characterization of these moieties.

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Year:  2008        PMID： 18204420     DOI： 10.1038/ni0208-113

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  12 in total

1.  Analysis of two major intracellular phospholipases A(2) (PLA(2)) in mast cells reveals crucial contribution of cytosolic PLA(2)α, not Ca(2+)-independent PLA(2)β, to lipid mobilization in proximal mast cells and distal fibroblasts.

Authors:  Noriko Ueno; Yoshitaka Taketomi; Kei Yamamoto; Tetsuya Hirabayashi; Daisuke Kamei; Yoshihiro Kita; Takao Shimizu; Koei Shinzawa; Yoshihide Tsujimoto; Kazutaka Ikeda; Ryo Taguchi; Makoto Murakami
Journal:  J Biol Chem       Date:  2011-08-31       Impact factor: 5.157

2.  Montelukast during primary infection prevents airway hyperresponsiveness and inflammation after reinfection with respiratory syncytial virus.

Authors:  Junyan Han; Yi Jia; Katsuyuki Takeda; Yoshiki Shiraishi; Masakazu Okamoto; Azzeddine Dakhama; Erwin W Gelfand
Journal:  Am J Respir Crit Care Med       Date:  2010-05-04       Impact factor: 21.405

Review 3.  The pathophysiology of anaphylaxis.

Authors:  Laurent L Reber; Joseph D Hernandez; Stephen J Galli
Journal:  J Allergy Clin Immunol       Date:  2017-08       Impact factor: 10.793

4.  Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia.

Authors:  Wei Zhang; Xuexin Zhang; José C González-Cobos; Judith A Stolwijk; Khalid Matrougui; Mohamed Trebak
Journal:  J Biol Chem       Date:  2014-12-24       Impact factor: 5.157

5.  A novel clade of cysteinyl leukotriene scavengers in soft ticks.

Authors:  Ben J Mans; José M C Ribeiro
Journal:  Insect Biochem Mol Biol       Date:  2008-07-15       Impact factor: 4.714

6.  Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity.

Authors:  Shabbir Ahmad; A Jimmy Ytterberg; Madhuranayaki Thulasingam; Fredrik Tholander; Tomas Bergman; Roman Zubarev; Anders Wetterholm; Agnes Rinaldo-Matthis; Jesper Z Haeggström
Journal:  J Biol Chem       Date:  2016-06-30       Impact factor: 5.157

7.  Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors.

Authors:  Akiko Maekawa; Yoshihide Kanaoka; Wei Xing; K Frank Austen
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-17       Impact factor: 11.205

8.  Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells.

Authors:  Nora A Barrett; Akiko Maekawa; Opu M Rahman; K Frank Austen; Yoshihide Kanaoka
Journal:  J Immunol       Date:  2009-01-15       Impact factor: 5.422

Review 9.  Microdialysis sampling techniques applied to studies of the foreign body reaction.

Authors:  Cynthia R Sides; Julie A Stenken
Journal:  Eur J Pharm Sci       Date:  2013-11-21       Impact factor: 4.384

Review 10.  Asthma genetics and personalised medicine.

Authors:  Deborah A Meyers; Eugene R Bleecker; John W Holloway; Stephen T Holgate
Journal:  Lancet Respir Med       Date:  2014-05-02       Impact factor: 30.700
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