AIM: To investigate whether the major kavalactone kavain imposes adverse effects on the liver ultrastructure and function by affecting vascular and microvascular architecture and altering hepatocellular morphology. METHODS: Kavain solution (10 microg/mL or 43.5 micromol/L) was perfused for 2 h in isolated rat livers. After standard fixation and tissue preparation, the samples were examined by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and light microscopy (LM). RESULTS: LM, SEM, and TEM examinations indicated kavain-treated rat livers (n=4) displayed severe vascular and endothelial damage compared to control livers (n=4). CONCLUSION: The data so far support the hypothesis that kavain induces adverse effects on liver; additional investigations with other kavalactones and their effects on liver are urgently needed.
AIM: To investigate whether the major kavalactone kavain imposes adverse effects on the liver ultrastructure and function by affecting vascular and microvascular architecture and altering hepatocellular morphology. METHODS:Kavain solution (10 microg/mL or 43.5 micromol/L) was perfused for 2 h in isolated rat livers. After standard fixation and tissue preparation, the samples were examined by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and light microscopy (LM). RESULTS: LM, SEM, and TEM examinations indicated kavain-treated rat livers (n=4) displayed severe vascular and endothelial damage compared to control livers (n=4). CONCLUSION: The data so far support the hypothesis that kavain induces adverse effects on liver; additional investigations with other kavalactones and their effects on liver are urgently needed.
Authors: M Kraft; T W Spahn; J Menzel; N Senninger; K H Dietl; H Herbst; W Domschke; M M Lerch Journal: Dtsch Med Wochenschr Date: 2001-09-07 Impact factor: 0.628
Authors: Mamta Behl; Abraham Nyska; Rajendra S Chhabra; Gregory S Travlos; Laurene M Fomby; Barney R Sparrow; Milton R Hejtmancik; Po C Chan Journal: Food Chem Toxicol Date: 2011-08-18 Impact factor: 6.023