OBJECTIVE: To assess whether lower adiponectin concentrations in South Asian Indians may be responsible for their greater degree of insulin resistance. RESEARCH DESIGN AND METHODS: Insulin-mediated glucose uptake and plasma total and high molecular weight (HMW) adiponectin concentrations were quantified in 52 women of South Asian (SA) and Caucasian (CAU) ancestry and compared. RESULTS: Mean +/- SD total (2,965 +/- 1,278 vs. 4,235 +/- 160 ng/ml) and HMW (1,001 +/- 352 vs. 1,591 +/- 854 ng/ml) adiponectin were lower in SAs than CAUs (P < 0.005). Insulin-resistant CAUs (CAU-IR) had lower total (2,665 +/- 1,040 vs. 5,133 +/- 1,086 ng/ml) and HMW (987 +/- 479 vs. 1,935 +/- 838 ng/ml) adiponectin than insulin-sensitive CAUs (CAU-IS) (P < 0.01), but there were no significant differences between insulin-resistant (SA-IR) and insulin-sensitive (SA-IS) SAs. HMW adiponectin did not differ between SA-IR and CAU-IR, but SA-IS had significantly lower adiponectin concentrations than CAU-IS. CONCLUSIONS: Insulin resistance status is not associated with significantly lower levels of adiponectin in these SA women, in contrast to the CAU women.
OBJECTIVE: To assess whether lower adiponectin concentrations in South Asian Indians may be responsible for their greater degree of insulin resistance. RESEARCH DESIGN AND METHODS: Insulin-mediated glucose uptake and plasma total and high molecular weight (HMW) adiponectin concentrations were quantified in 52 women of South Asian (SA) and Caucasian (CAU) ancestry and compared. RESULTS: Mean +/- SD total (2,965 +/- 1,278 vs. 4,235 +/- 160 ng/ml) and HMW (1,001 +/- 352 vs. 1,591 +/- 854 ng/ml) adiponectin were lower in SAs than CAUs (P < 0.005). Insulin-resistant CAUs (CAU-IR) had lower total (2,665 +/- 1,040 vs. 5,133 +/- 1,086 ng/ml) and HMW (987 +/- 479 vs. 1,935 +/- 838 ng/ml) adiponectin than insulin-sensitive CAUs (CAU-IS) (P < 0.01), but there were no significant differences between insulin-resistant (SA-IR) and insulin-sensitive (SA-IS) SAs. HMW adiponectin did not differ between SA-IR and CAU-IR, but SA-IS had significantly lower adiponectin concentrations than CAU-IS. CONCLUSIONS:Insulin resistance status is not associated with significantly lower levels of adiponectin in these SA women, in contrast to the CAU women.
Authors: Andrew Mente; Fahad Razak; Stefan Blankenberg; Vlad Vuksan; A Darlene Davis; Ruby Miller; Koon Teo; Hertzel Gerstein; Arya M Sharma; Salim Yusuf; Sonia S Anand Journal: Diabetes Care Date: 2010-04-22 Impact factor: 19.112
Authors: Shannon M Conroy; Weiwen Chai; Unhee Lim; Adrian A Franke; Robert V Cooney; Gertraud Maskarinec Journal: Mediators Inflamm Date: 2011-02-08 Impact factor: 4.711
Authors: Sonia S Anand; Mark A Tarnopolsky; Shirya Rashid; Karleen M Schulze; Dipika Desai; Andrew Mente; Sandy Rao; Salim Yusuf; Hertzel C Gerstein; Arya M Sharma Journal: PLoS One Date: 2011-07-28 Impact factor: 3.240