Literature DB >> 1820208

A short leader sequence impairs the fidelity of initiation by eukaryotic ribosomes.

M Kozak1.   

Abstract

The functional consequences of unusually short 5' noncoding sequences on eukaryotic mRNAs are explored here by using an in vitro transcription and translation system. As the distance of the first AUG codon from the m7G cap was decreased from 32 to 3 nucleotides, the yield of protein initiated from the first AUG codon progressively decreased, with a corresponding increase in initiation from the second AUG codon. The leakiness attributable to a too-short leader sequence was offset, however, by introducing secondary structure downstream from the first AUG codon.

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Year:  1991        PMID： 1820208      PMCID： PMC5952205     

Source DB:  PubMed          Journal:  Gene Expr        ISSN： 1052-2166


  27 in total

1.  Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes.

Authors:  M Kozak
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

2.  Effects of long 5' leader sequences on initiation by eukaryotic ribosomes in vitro.

Authors:  M Kozak
Journal:  Gene Expr       Date:  1991-05

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Authors:  M Strubin; E O Long; B Mach
Journal:  Cell       Date:  1986-11-21       Impact factor: 41.582

5.  The gene encoding the beta-subunit of rat luteinizing hormone. Analysis of gene structure and evolution of nucleotide sequence.

Authors:  L Jameson; W W Chin; A N Hollenberg; A S Chang; J F Habener
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6.  The gene for the beta subunit of bovine luteinizing hormone encodes a gonadotropin mRNA with an unusually short 5'-untranslated region.

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Journal:  J Biol Chem       Date:  1985-06-10       Impact factor: 5.157

7.  Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.

Authors:  M Kozak
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8.  Isolation of the bovine and human genes for Müllerian inhibiting substance and expression of the human gene in animal cells.

Authors:  R L Cate; R J Mattaliano; C Hession; R Tizard; N M Farber; A Cheung; E G Ninfa; A Z Frey; D J Gash; E P Chow
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9.  Structure and expression analyses of the S-adenosylmethionine synthetase gene family in Arabidopsis thaliana.

Authors:  J Peleman; K Saito; B Cottyn; G Engler; J Seurinck; M Van Montagu; D Inzé
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  82 in total

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5.  The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation.

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Journal:  Genes Dev       Date:  2007-12-01       Impact factor: 11.361

6.  Effects of long 5' leader sequences on initiation by eukaryotic ribosomes in vitro.

Authors:  M Kozak
Journal:  Gene Expr       Date:  1991-05

7.  Trans-regulation of the expression of the transcription factor MtHAP2-1 by a uORF controls root nodule development.

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8.  Translation of the human papillomavirus type 16 E7 oncoprotein from bicistronic mRNA is independent of splicing events within the E6 open reading frame.

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Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

9.  Evolutionary analysis of mammalian enamelin, the largest enamel protein, supports a crucial role for the 32-kDa peptide and reveals selective adaptation in rodents and primates.

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10.  Differential processing and localization of human Nocturnin controls metabolism of mRNA and nicotinamide adenine dinucleotide cofactors.

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