Literature DB >> 1820197

Complete nucleotide and deduced protein sequence of CMP-NeuAc: poly-alpha-2,8 sialosyl sialyltransferase of Escherichia coli K1.

C Weisgerber1, A Hansen, M Frosch.   

Abstract

Poly-alpha-2,8 N-acetylneuraminic acid (polySia) is an important virulence factor in infections caused by Escherichia coli K1 and Neisseria meningitidis B. In E. coli K1 a membranous CMP-NeuAc: poly-alpha-2,8 sialosyl sialyltransferase (polysialyltransferase) complex catalyses the synthesis of linear polySia chains. The complex also elongates sialyl oligomers that serve as exogenous acceptors. The gene encoding a polysialyltransferase of E. coli has been identified by subcloning and DNA sequence analysis. The subcloned DNA fragment codes for a polypeptide with a molecular mass of 47 kDa catalysing the in vitro synthesis of polySia by elongation of exogenous acceptors.

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Year:  1991        PMID： 1820197     DOI： 10.1093/glycob/1.4.357

Source DB:  PubMed          Journal:  Glycobiology        ISSN： 0959-6658            Impact factor:   4.313


  6 in total

1.  Homology among Escherichia coli K1 and K92 polysialytransferases.

Authors:  E R Vimr; R Bergstrom; S M Steenbergen; G Boulnois; I Roberts
Journal:  J Bacteriol       Date:  1992-08       Impact factor: 3.490

2.  Genes associated with meningococcal capsule complex are also found in Neisseria gonorrhoeae.

Authors:  H Petering; S Hammerschmidt; M Frosch; J P van Putten; C A Ison; B D Robertson
Journal:  J Bacteriol       Date:  1996-06       Impact factor: 3.490

3.  Polysialic acid engineering: synthesis of polysialylated neoglycosphingolipids by using the polysialyltransferase from neuroinvasive Escherichia coli K1.

Authors:  J W Cho; F A Troy
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-22       Impact factor: 11.205

4.  Molecular cloning and analysis of genes for sialic acid synthesis in Neisseria meningitidis group B and purification of the meningococcal CMP-NeuNAc synthetase enzyme.

Authors:  S Ganguli; G Zapata; T Wallis; C Reid; G Boulnois; W F Vann; I S Roberts
Journal:  J Bacteriol       Date:  1994-08       Impact factor: 3.490

5.  Nucleotide sequence and genetic analysis of the neuD and neuB genes in region 2 of the polysialic acid gene cluster of Escherichia coli K1.

Authors:  P W Annunziato; L F Wright; W F Vann; R P Silver
Journal:  J Bacteriol       Date:  1995-01       Impact factor: 3.490

6.  Biochemical characterization of a Neisseria meningitidis polysialyltransferase reveals novel functional motifs in bacterial sialyltransferases.

Authors:  Friedrich Freiberger; Heike Claus; Almut Günzel; Imke Oltmann-Norden; Justine Vionnet; Martina Mühlenhoff; Ulrich Vogel; Willie F Vann; Rita Gerardy-Schahn; Katharina Stummeyer
Journal:  Mol Microbiol       Date:  2007-07-27       Impact factor: 3.501
  6 in total

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