| Literature DB >> 18201806 |
Valéria A Conforti1, David M de Avila, Nada S Cummings, Ricardo Zanella, Kenny J Wells, Hasan Ulker, Jerry J Reeves.
Abstract
This study compared: (1) Freund's complete adjuvant and CpG oligodeoxynucleotide (ODN) 2006 in water-in-oil emulsion as adjuvants; and (2) increasing doses of a recombinant ovalbumin-LHRH (ova-LHRH) fusion protein as an antigen for a contraceptive vaccine. Treatment groups (n=8 heifers/group) were: one untreated control group; five groups receiving CpG ODN with different doses of ova-LHRH (1.5; 2.3; 3.4; 5.1; and 7.6 mg); and one group receiving 3.4 mg ova-LHRH in Freund's. Heifers were immunized at weeks 0 and 14. All vaccine treatments caused gonadal regression and estrus suppression. CpG ODN is a suitable replacement for Freund's for LHRH immunization.Entities:
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Year: 2007 PMID： 18201806 DOI： 10.1016/j.vaccine.2007.12.010
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641