Literature DB >> 18201756

GABA(A) receptor subtypes underlying general anesthesia.

Robert P Bonin1, Beverley A Orser.   

Abstract

General anesthetics produce a constellation of behavioral responses and widespread neurodepression. Recent studies have implicated the gamma-aminobutyric acid (GABA) subtype A receptor as a primary anesthetic target. During the past decade, considerable progress has been made in dissecting the behavioral effects of anesthetics according to the subunit composition of GABA(A) receptors. In this review, we describe how particular GABA(A) receptor subtypes expressed in different brain regions are critical for the expression of behavioral endpoints, such as amnesia, sedation, and hypnosis.

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Year:  2008        PMID： 18201756     DOI： 10.1016/j.pbb.2007.12.011

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  34 in total

Review 1.  Awareness during anesthesia.

Authors:  Beverley A Orser; C David Mazer; Andrew J Baker
Journal:  CMAJ       Date:  2007-12-11       Impact factor: 8.262

Review 2.  New insights in the systemic and molecular underpinnings of general anesthetic actions mediated by γ-aminobutyric acid A receptors.

Authors:  Bernd Antkowiak; Uwe Rudolph
Journal:  Curr Opin Anaesthesiol       Date:  2016-08       Impact factor: 2.706

Review 3.  Structural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptor.

Authors:  Gustav Akk; Joe Henry Steinbach
Journal:  Anesthesiology       Date:  2011-12       Impact factor: 7.892

4.  MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity.

Authors:  Jean-Pierre Rosso; Jürgen R Schwarz; Marcelo Diaz-Bustamante; Brigitte Céard; José M Gutiérrez; Matthias Kneussel; Olaf Pongs; Frank Bosmans; Pierre E Bougis
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-09       Impact factor: 11.205

5.  GABAA receptors involved in sleep and anaesthesia: β1- versus β3-containing assemblies.

Authors:  Yevgenij Yanovsky; Stephan Schubring; Wiebke Fleischer; Günter Gisselmann; Xin-Ran Zhu; Hermann Lübbert; Hanns Hatt; Uwe Rudolph; Helmut L Haas; Olga A Sergeeva
Journal:  Pflugers Arch       Date:  2011-07-07       Impact factor: 3.657

6.  Awake nonhuman primate brain PET imaging with minimal head restraint: evaluation of GABAA-benzodiazepine binding with 11C-flumazenil in awake and anesthetized animals.

Authors:  Christine M Sandiego; Xiao Jin; Tim Mulnix; Krista Fowles; David Labaree; Jim Ropchan; Yiyun Huang; Kelly Cosgrove; Stacy A Castner; Graham V Williams; Lisa Wells; Eugenii A Rabiner; Richard E Carson
Journal:  J Nucl Med       Date:  2013-10-10       Impact factor: 10.057

Review 7.  The recent progress in research on effects of anesthetics and analgesics on G protein-coupled receptors.

Authors:  Kouichiro Minami; Yasuhito Uezono
Journal:  J Anesth       Date:  2012-10-26       Impact factor: 2.078

8.  Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors.

Authors:  Guo-Dong Li; David C Chiara; Jonathan B Cohen; Richard W Olsen
Journal:  J Biol Chem       Date:  2010-01-18       Impact factor: 5.157

9.  Distinct α subunit variations of the hypothalamic GABAA receptor triplets (αβγ) are linked to hibernating state in hamsters.

Authors:  Raffaella Alò; Ennio Avolio; Anna Di Vito; Antonio Carelli; Rosa Maria Facciolo; Marcello Canonaco
Journal:  BMC Neurosci       Date:  2010-09-06       Impact factor: 3.288

10.  Glycine receptors contribute to hypnosis induced by ethanol.

Authors:  Jiang H Ye; Kimberly A Sokol; Urvi Bhavsar
Journal:  Alcohol Clin Exp Res       Date:  2009-03-23       Impact factor: 3.455
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