Cem Meco1, Erich Arrer, Gerhard Oberascher. 1. Department of Otorhinolaryngology- Head and Neck Surgery, Salzburg Paracelsus University Medical School, Salzburg, Austria. c.meco@salk.at
Abstract
BACKGROUND: After cerebrospinal fluid (CSF) fistula repair, the goal of watertight sealing may not always be achieved, causing postoperative CSF leakage. The aim of this study was to assess the novel application of the beta-trace protein (betaTP) test for postoperative screening and confirmation of dura repair success. METHODS: Prospectively, we investigated 32 consecutive patients who underwent dura repair. Postoperative nasal secretion and serum were analyzed for CSF marker betaTP, to detect or rule out postoperative CSF leakage. RESULTS: In 29 patients no CSF was detected, indicating 91% dura repair success after the first step. Three patients required additional surgery, verifying CSF leak. Additional betaTP testing was negative, revealing successful dura repair. CONCLUSION: Dura repairs should be controlled for the presence or absence of postoperative CSF leakage. In our hands, the sensitive, fast, and inexpensive betaTP test has shown its value as an effective postoperative screening tool for dura repair success confirmation. Therefore, we consider it as novel "standard of care" and reserve invasive, more expensive or time-consuming methods as second choice.
BACKGROUND: After cerebrospinal fluid (CSF) fistula repair, the goal of watertight sealing may not always be achieved, causing postoperative CSF leakage. The aim of this study was to assess the novel application of the beta-trace protein (betaTP) test for postoperative screening and confirmation of dura repair success. METHODS: Prospectively, we investigated 32 consecutive patients who underwent dura repair. Postoperative nasal secretion and serum were analyzed for CSF marker betaTP, to detect or rule out postoperative CSF leakage. RESULTS: In 29 patients no CSF was detected, indicating 91% dura repair success after the first step. Three patients required additional surgery, verifying CSF leak. Additional betaTP testing was negative, revealing successful dura repair. CONCLUSION: Dura repairs should be controlled for the presence or absence of postoperative CSF leakage. In our hands, the sensitive, fast, and inexpensive betaTP test has shown its value as an effective postoperative screening tool for dura repair success confirmation. Therefore, we consider it as novel "standard of care" and reserve invasive, more expensive or time-consuming methods as second choice.
Authors: Veli Citisli; Murat Kocaoglu; Ceyda Necan; Muhammet İbrahimoglu; Özkan Celiker; Eyüp Baykara; Mevci Ozdemir; Feridun Acar; Mehmet Erdal Coskun Journal: Int J Health Sci (Qassim) Date: 2015-04
Authors: Manuel Bernal-Sprekelsen; Elena Rioja; Joaquim Enseñat; Karla Enriquez; Liza Viscovich; Freddy Enrique Agredo-Lemos; Isam Alobid Journal: Biomed Res Int Date: 2014-05-07 Impact factor: 3.411