Vera Maria Freitas da Silveira1, Bernardo Lessa Horta. 1. Programa de Pós graduação em Epidemiologia, Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, RS, Brasil. veramfs@terra.com.br
Abstract
OBJECTIVES: To assess published evidences of the effect of birth weight on metabolic syndrome in adults. METHODS: PubMed and LILACS databases were searched for articles published from 1966 through May 2006. The terms used were: "birth weight", "birthweight", "intra-uterine growth restriction (IUGR)", "fetal growth retardation", "metabolic syndrome", "syndrome X", "Reaven's X syndrome". Two hundred and twenty-four studies reporting estimates of the association between birth weight and metabolic syndrome or its components were considered eligible. Eleven studies provided odds ratios and were included in the meta-analysis. RESULTS: All but two studies reported an inverse relationship between birth weight and metabolic syndrome. A comparison between low birth weight vs. normal birth weight subjects showed the random effects odds ratio for metabolic syndrome was 2.53 (95% CI: 1.57;4.08). The funnel plot graphic suggests a publication bias but, even in the studies with more than 400 subjects, the results remained significant (pooled odds ratio: 2.37 (95% CI: 1.15;4.90). CONCLUSIONS: Low birth weight increases the risk of metabolic syndrome in adults.
OBJECTIVES: To assess published evidences of the effect of birth weight on metabolic syndrome in adults. METHODS: PubMed and LILACS databases were searched for articles published from 1966 through May 2006. The terms used were: "birth weight", "birthweight", "intra-uterine growth restriction (IUGR)", "fetal growth retardation", "metabolic syndrome", "syndrome X", "Reaven's X syndrome". Two hundred and twenty-four studies reporting estimates of the association between birth weight and metabolic syndrome or its components were considered eligible. Eleven studies provided odds ratios and were included in the meta-analysis. RESULTS: All but two studies reported an inverse relationship between birth weight and metabolic syndrome. A comparison between low birth weight vs. normal birth weight subjects showed the random effects odds ratio for metabolic syndrome was 2.53 (95% CI: 1.57;4.08). The funnel plot graphic suggests a publication bias but, even in the studies with more than 400 subjects, the results remained significant (pooled odds ratio: 2.37 (95% CI: 1.15;4.90). CONCLUSIONS: Low birth weight increases the risk of metabolic syndrome in adults.
Authors: Dan Xu; Li-ping Xia; Lang Shen; You-ying Lei; Lian Liu; Li Zhang; Jacques Magdalou; Hui Wang Journal: Acta Pharmacol Sin Date: 2013-11-25 Impact factor: 6.150
Authors: Dan Xu; Benjian Zhang; Gai Liang; Jie Ping; Hao Kou; Xiaojun Li; Jie Xiong; Dongcai Hu; Liaobin Chen; Jacques Magdalou; Hui Wang Journal: PLoS One Date: 2012-09-06 Impact factor: 3.240