Literature DB >> 18199471

Telomere and adaptive immunity.

Nan-ping Weng1.   

Abstract

The adaptive immune response relies on the ability of lymphocytes to undergo periodic massive expansion. It is an enigma how lymphocytes are able to undergo this seemingly unlimited number of cell divisions. Telomeres and telomerase play a critical role in regulation of the replicative lifespan of cells, providing a potential mechanism which lymphocytes may employ. Here I will review the recent progress of the role of telomeres and telomerase in lymphocyte differentiation, function, and aging.

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Year:  2007        PMID： 18199471      PMCID： PMC2276146          DOI： 10.1016/j.mad.2007.11.005

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  59 in total

1.  A telomerase component is defective in the human disease dyskeratosis congenita.

Authors:  J R Mitchell; E Wood; K Collins
Journal:  Nature       Date:  1999-12-02       Impact factor: 49.962

2.  Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase.

Authors:  E Hooijberg; J J Ruizendaal; P J Snijders; E W Kueter; J M Walboomers; H Spits
Journal:  J Immunol       Date:  2000-10-15       Impact factor: 5.422

3.  Virus-induced CD8+ T cell clonal expansion is associated with telomerase up-regulation and telomere length preservation: a mechanism for rescue from replicative senescence.

Authors:  M K Maini; M V Soares; C F Zilch; A N Akbar; P C Beverley
Journal:  J Immunol       Date:  1999-04-15       Impact factor: 5.422

Review 4.  Regulation of telomere length and telomerase in T and B cells: a mechanism for maintaining replicative potential.

Authors:  N P Weng; K S Hathcock; R J Hodes
Journal:  Immunity       Date:  1998-08       Impact factor: 31.745

5.  Telomerase activity in human germline and embryonic tissues and cells.

Authors:  W E Wright; M A Piatyszek; W E Rainey; W Byrd; J W Shay
Journal:  Dev Genet       Date:  1996

6.  Inhibition of telomerase limits the growth of human cancer cells.

Authors:  W C Hahn; S A Stewart; M W Brooks; S G York; E Eaton; A Kurachi; R L Beijersbergen; J H Knoll; M Meyerson; R A Weinberg
Journal:  Nat Med       Date:  1999-10       Impact factor: 53.440

7.  In vivo reduction of telomere length in human antigen-reactive memory T cells.

Authors:  J B Burns; S T Lobo; B D Bartholomew
Journal:  Eur J Immunol       Date:  2000-07       Impact factor: 5.532

8.  Accelerated telomere shortening in response to life stress.

Authors:  Elissa S Epel; Elizabeth H Blackburn; Jue Lin; Firdaus S Dhabhar; Nancy E Adler; Jason D Morrow; Richard M Cawthon
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-01       Impact factor: 11.205

9.  Association of immune abnormalities with telomere shortening in autosomal-dominant dyskeratosis congenita.

Authors:  Matt Knudson; Shashikant Kulkarni; Zuhair K Ballas; Monica Bessler; Frederick Goldman
Journal:  Blood       Date:  2004-07-06       Impact factor: 22.113

10.  Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood.

Authors:  N Rufer; T H Brümmendorf; S Kolvraa; C Bischoff; K Christensen; L Wadsworth; M Schulzer; P M Lansdorp
Journal:  J Exp Med       Date:  1999-07-19       Impact factor: 14.307
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  30 in total

1.  Increased vitamin D is associated with decline of naïve, but accumulation of effector, CD8 T cells during early aging.

Authors:  Yong Gil Hwang; Hui-Chen Hsu; Fei-Chu Lim; Qi Wu; PingAr Yang; Gordon Fisher; Gary R Hunter; John D Mountz
Journal:  Adv Aging Res       Date:  2013-05

Review 2.  Telomeres and immune competency.

Authors:  Nan-ping Weng
Journal:  Curr Opin Immunol       Date:  2012-05-22       Impact factor: 7.486

Review 3.  Aging and immune function: molecular mechanisms to interventions.

Authors:  Subramaniam Ponnappan; Usha Ponnappan
Journal:  Antioxid Redox Signal       Date:  2011-01-08       Impact factor: 8.401

4.  Improved procedure for the measurement of telomere length in whole cells by PNA probe and flow cytometry.

Authors:  M Carbonari; D Mancaniello; M Cibati; A Catizone; M Fiorilli
Journal:  Cell Prolif       Date:  2010-12       Impact factor: 6.831

Review 5.  Telomeres and immunological diseases of aging.

Authors:  Nicolas P Andrews; Hiroshi Fujii; Jörg J Goronzy; Cornelia M Weyand
Journal:  Gerontology       Date:  2009-12-17       Impact factor: 5.140

Review 6.  Genetic and epigenetic trends in telomere research: a novel way in immunoepigenetics.

Authors:  Dora Melicher; Edit I Buzas; Andras Falus
Journal:  Cell Mol Life Sci       Date:  2015-07-20       Impact factor: 9.261

7.  Telomere Length as an Indicator of the Robustness of B- and T-Cell Response to Influenza in Older Adults.

Authors:  Kevin Najarro; Huy Nguyen; Guobing Chen; Mai Xu; Sandy Alcorta; Xu Yao; Linda Zukley; E Jeffrey Metter; Thai Truong; Yun Lin; Huifen Li; Mathias Oelke; Xiyan Xu; Shari M Ling; Dan L Longo; Jonathan Schneck; Sean Leng; Luigi Ferrucci; Nan-ping Weng
Journal:  J Infect Dis       Date:  2015-03-31       Impact factor: 5.226

8.  Sepsis induces telomere shortening: a potential mechanism responsible for delayed pathophysiological events in sepsis survivors?

Authors:  Naara Mendes Oliveira; Ester C S Rios; Thais Martins de Lima; Vanessa Jacob Victorino; Hermes Barbeiro; Fabiano Pinheiro da Silva; Csaba Szabo; Francisco Garcia Soriano
Journal:  Mol Med       Date:  2016-12-05       Impact factor: 6.354

9.  The CD27+ memory B cells display changes in the gene expression pattern in elderly individuals.

Authors:  Alicia Báez; Isabel Alvarez-Laderas; José I Piruat; Teresa Caballero-Velázquez; M Victoria Barbado; Africa Millán-Uclés; Mayte Medrano; Estefanía García-Guerrero; Li Sánchez-Abarca; José Antonio Pérez-Simón
Journal:  Immunology       Date:  2014-09-06       Impact factor: 7.397

10.  Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance.

Authors:  Jue Lin; Elissa Epel; Joshua Cheon; Candyce Kroenke; Elizabeth Sinclair; Marty Bigos; Owen Wolkowitz; Synthia Mellon; Elizabeth Blackburn
Journal:  J Immunol Methods       Date:  2009-10-21       Impact factor: 2.303
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