Literature DB >> 18199409

Genetic background and the dilemma of translating mouse studies to humans.

Juan Rivera1, Lino Tessarollo.   

Abstract

C57BL/6 genetically modified mouse models are the accepted gold standard in biological studies. However, an increasing failure of translating the findings to human (patho)physiology casts doubt on using a single strain to address many questions.

Entities:  

Mesh：

Year:  2008        PMID： 18199409     DOI： 10.1016/j.immuni.2007.12.008

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  51 in total

1.  Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4.

Authors:  Jianlin Chen; John R Hartono; Reji John; Michael Bennett; Xin Jin Zhou; Yanxia Wang; Qingqing Wu; Pamela D Winterberg; Glenn T Nagami; Christopher Y Lu
Journal:  Kidney Int       Date:  2011-06-01       Impact factor: 10.612

Review 2.  Designing phenotyping studies for genetically engineered mice.

Authors:  C J Zeiss; J M Ward; H G Allore
Journal:  Vet Pathol       Date:  2011-09-19       Impact factor: 2.221

3.  A preclinical rodent model of radiation-induced lung injury for medical countermeasure screening in accordance with the FDA animal rule.

Authors:  Isabel L Jackson; Puting Xu; Caroline Hadley; Barry P Katz; Ross McGurk; Julian D Down; Zeljko Vujaskovic
Journal:  Health Phys       Date:  2012-10       Impact factor: 1.316

Review 4.  Adapters in the organization of mast cell signaling.

Authors:  Damiana Alvarez-Errico; Eva Lessmann; Juan Rivera
Journal:  Immunol Rev       Date:  2009-11       Impact factor: 12.988

5.  Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.

Authors:  Jonathan A Hensel; Vinayak Khattar; Reading Ashton; Selvarangan Ponnazhagan
Journal:  Lab Invest       Date:  2018-10-23       Impact factor: 5.662

6.  Rodent models of focal cerebral ischemia: procedural pitfalls and translational problems.

Authors:  Stefan Braeuninger; Christoph Kleinschnitz
Journal:  Exp Transl Stroke Med       Date:  2009-11-25

7.  In vitro and in vivo anticancer properties of a Calcarea carbonica derivative complex (M8) treatment in a murine melanoma model.

Authors:  Fernando S F Guimarães; Lucas F Andrade; Sharon T Martins; Ana P R Abud; Reginaldo V Sene; Carla Wanderer; Inés Tiscornia; Mariela Bollati-Fogolín; Dorly F Buchi; Edvaldo S Trindade
Journal:  BMC Cancer       Date:  2010-03-25       Impact factor: 4.430

8.  Outcome of experimental stroke in C57Bl/6 and Sv/129 mice assessed by multimodal ultra-high field MRI.

Authors:  Mirko Pham; Xavier Helluy; Stefan Braeuninger; Peter Jakob; Guido Stoll; Christoph Kleinschnitz; Martin Bendszus
Journal:  Exp Transl Stroke Med       Date:  2010-03-15

9.  Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.

Authors:  Douglas C Wilson; Gijsbert M Grotenbreg; Kenian Liu; Yanlin Zhao; Eva-Maria Frickel; Marc-Jan Gubbels; Hidde L Ploegh; George S Yap
Journal:  PLoS Pathog       Date:  2010-03-19       Impact factor: 6.823

10.  Electroporation markedly improves Sleeping Beauty transposon-induced tumorigenesis in mice.

Authors:  S Jung; H-J Choi; H-K Park; W Jo; S Jang; J-E Ryu; W-J Kim; E-S Yu; W-C Son
Journal:  Cancer Gene Ther       Date:  2014-07-04       Impact factor: 5.987
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