Inhibition of dermal MRSA colonization by microalgal micro- and nanoparticles.

The aim of this study was to investigate the prevention of the dermal colonization of methicillin-resistant Staphylococcus aureus (MRSA) strains by the application of micro- and nanoparticles called Maresometrade mark. Maresometrade mark were prepared from selected microalgae by a novel emulsion technique. They contain lipids and all other components of the microalgae in an encapsulated form. It could be shown that Maresometrade mark prepared from a cyanobacterial strain of the order Nostocales (Bio33-Maresometrade mark) were able to inhibit the dermal colonization of different MRSA strains (North German Epidemic Strain, Col, N315) and even of the vancomycin-resistant strain MU50 in the models 'mouse ear' and 'cow udder teat'. Pretreatment of the skin with Maresometrade mark reduced the number of attached MRSA by 3-4 log units in comparison to the control. We assume that a prophylactic skin care with Maresometrade mark could complete the multibarrier anti-infectious strategy against MRSA. (c) 2008 S. Karger AG, Basel