| Literature DB >> 18198002 |
C Lanzas1, S Brien, R Ivanek, Y Lo, P P Chapagain, K A Ray, P Ayscue, L D Warnick, Y T Gröhn.
Abstract
The objective of this study was to address the impact of heterogeneity of infectious period and contagiousness on Salmonella transmission dynamics in dairy cattle populations. We developed three deterministic SIR-type models with two basic infected stages (clinically and subclinically infected). In addition, model 2 included long-term shedders, which were defined as individuals with low contagiousness but long infectious period, and model 3 included super-shedders (individuals with high contagiousness and long infectious period). The simulated dynamics, basic reproduction number (R0) and critical vaccination threshold were studied. Clinically infected individuals were the main force of infection transmission for models 1 and 2. Long-term shedders had a small impact on the transmission of the infection and on the estimated vaccination thresholds. The presence of super-shedders increases R0 and decreases the effectiveness of population-wise strategies to reduce infection, making necessary the application of strategies that target this specific group.Entities:
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Year: 2008 PMID： 18198002 PMCID： PMC2870740 DOI： 10.1017/S0950268807000209
Source DB: PubMed Journal: Epidemiol Infect ISSN： 0950-2688 Impact factor: 2.451