Literature DB >> 18197471

Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation.

Tao T Zhang1, Jimcy Platholi, Paul M Heerdt, Hugh C Hemmings, H Y L Tung.   

Abstract

Protein phosphatase-2A (PP-2A) interacts with several regulators of cell death pathways and is therefore a potential component of signaling pathways linking global cerebral ischemia to cell death. Using a novel procedure to quantify PP-2A activity, we find that cardiac arrest with resuscitation and reperfusion leads to activation of PP-2A by 1.6-fold in pig brain extract and by 3.4-fold after partial purification of PP-2A. This is the first demonstration of PP-2A activation in a clinically relevant model of transient global cerebral ischemia. These results suggest that inhibition of PP-2A activity may be neuroprotective in global cerebral ischemia.

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Year:  2008        PMID： 18197471     DOI： 10.1007/s11011-007-9074-1

Source DB:  PubMed          Journal:  Metab Brain Dis        ISSN： 0885-7490            Impact factor:   3.584


  47 in total

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Journal:  Neuroscience       Date:  2000       Impact factor: 3.590

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  2 in total

1.  Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia.

Authors:  Christoph P Hofstetter; Jan-Karl Burkhardt; Benjamin J Shin; Demirkan B Gürsel; Lynn Mubita; Ramana Gorrepati; Cameron Brennan; Eric C Holland; John A Boockvar
Journal:  PLoS One       Date:  2012-01-11       Impact factor: 3.240

2.  Activation of protein kinase C delta following cerebral ischemia leads to release of cytochrome C from the mitochondria via bad pathway.

Authors:  Kunjan R Dave; Sanjoy K Bhattacharya; Isabel Saul; R Anthony DeFazio; Cameron Dezfulian; Hung Wen Lin; Ami P Raval; Miguel A Perez-Pinzon
Journal:  PLoS One       Date:  2011-07-15       Impact factor: 3.240
  2 in total

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