Literature DB >> 18197390

Blockade of corticoliberin receptors prevents the development of post-stress psychopathology in rats with an active strategy of adaptive behavior.

O G Semenova1, V V Rakitskaya, V G Shalyapina.   

Abstract

Active and passive Wistar rats were subjected to single water immersions, after which they showed signs of post-stress depression. Administration on this background of the peptide CRH-R1 receptor blocker astressin prevented the development of behavioral deficit in active individuals but had no effect on the behavior of passive rats. These results lead to the conclusion that corticoliberin receptor blockers are effective in the treatment of post-stress depression only for individuals with an initially active behavioral strategy.

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Year:  2008        PMID： 18197390     DOI： 10.1007/s11055-008-0031-1

Source DB:  PubMed          Journal:  Neurosci Behav Physiol        ISSN： 0097-0549


  22 in total

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Authors:  V G Shaliapina; V V Rakitskaia; M G Semenova; O G Semenova
Journal:  Ross Fiziol Zh Im I M Sechenova       Date:  2006-04

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Authors:  C B Nemeroff
Journal:  Mol Psychiatry       Date:  1996-09       Impact factor: 15.992

Review 5.  Corticotropin-releasing hormone in depression and post-traumatic stress disorder.

Authors:  J W Kasckow; D Baker; T D Geracioti
Journal:  Peptides       Date:  2001-05       Impact factor: 3.750

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Journal:  JAMA       Date:  1992-03-04       Impact factor: 56.272

7.  Anxiolytic- and antidepressant-like profile of a new CRF1 receptor antagonist, R278995/CRA0450.

Authors:  Shigeyuki Chaki; Atsuro Nakazato; Ludo Kennis; Masato Nakamura; Claire Mackie; Masayuki Sugiura; Petra Vinken; David Ashton; Xavier Langlois; Thomas Steckler
Journal:  Eur J Pharmacol       Date:  2004-02-06       Impact factor: 4.432

8.  "Behavioral despair" test predicts stress ulcer in WKY rats.

Authors:  W P Paré
Journal:  Physiol Behav       Date:  1989-09

9.  Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.

Authors:  C B Nemeroff; M J Owens; G Bissette; A C Andorn; M Stanley
Journal:  Arch Gen Psychiatry       Date:  1988-06

10.  [Adaptive behavior of active and passive rats after intranasal administration of the corticotropin-releasing hormone].

Authors:  V G Shaliapina; V V Rakitskaia; E I Petrova; V I Mironova
Journal:  Ross Fiziol Zh Im I M Sechenova       Date:  2002-09
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