Literature DB >> 1819732

The effect of CV-3988 and CV-6209 on the acute gastric erosions of rats due to water-immersion and restraint stress.

M Nogami1, Y Hoshihara, K Tsubura, T Yamamoto, M Tabuchi, T Miyamoto, J Shiga.   

Abstract

CV-3988 and CV-6209 inhibited gastric erosions in rats due to water-immersion and restraint stress in a dose-dependent manner. The above inhibitory effects of CV-3988 were observed in the presence of indomethacin, which may indicate that the inhibition is not prostaglandin dependent. The studies indicate that platelet-activating factor may be involved in the formation of erosions in rats under water-immersion and restraint stress.

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Year:  1991        PMID： 1819732     DOI： 10.1007/BF02536565

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  8 in total

1.  [Effects of a platelet activating factor (PAF) antagonist CV-3988 on acute gastric erosions in rats by water immersion and restrained stress, and by ethanol].

Authors:  M Nogami; Y Hoshihara; K Tsubura; T Yamamoto; M Tabuchi; T Miyamoto; J Shiga
Journal:  Nihon Shokakibyo Gakkai Zasshi       Date:  1988-10

2.  The effects of drugs on the production and recovery processes of the stress ulcer.

Authors:  K Takagi; S Okabe
Journal:  Jpn J Pharmacol       Date:  1968-03

3.  Effects of the specific platelet-activating factor antagonists, BN 52021 and BN 52063, on various experimental gastrointestinal ulcerations.

Authors:  P Braquet; A Etienne; J M Mencia-Huerta; F Clostre
Journal:  Eur J Pharmacol       Date:  1988-06-10       Impact factor: 4.432

4.  Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury.

Authors:  A Robert; J E Nezamis; C Lancaster; A J Hanchar
Journal:  Gastroenterology       Date:  1979-09       Impact factor: 22.682

5.  CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo.

Authors:  Z Terashita; Y Imura; M Takatani; S Tsushima; K Nishikawa
Journal:  J Pharmacol Exp Ther       Date:  1987-07       Impact factor: 4.030

6.  Antiulcer and gastroprotective effects of solon, a synthetic flavonoid derivative of sophoradin. Role of endogenous prostaglandins.

Authors:  S J Konturek; T Radecki; T Brzozowski; D Drozdowicz; I Piastucki; M Muramatsu; M Tanaka; H Aihara
Journal:  Eur J Pharmacol       Date:  1986-06-17       Impact factor: 4.432

7.  Potent ulcerogenic actions of platelet-activating factor on the stomach.

Authors:  A C Rosam; J L Wallace; B J Whittle
Journal:  Nature       Date:  1986 Jan 2-8       Impact factor: 49.962

8.  CV-3988 - a specific antagonist of platelet activating factor (PAF).

Authors:  Z Terashita; S Tsushima; Y Yoshioka; H Nomura; Y Inada; K Nishikawa
Journal:  Life Sci       Date:  1983-04-25       Impact factor: 5.037
  8 in total

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