Literature DB >> 1819729

Hypoxia, PAF, and necrotizing enterocolitis.

M S Caplan1, X M Sun, W Hsueh.   

Abstract

Necrotizing enterocolitis (NEC) is an important neonatal disease with a high mortality rate. The pathophysiology is unclear but epidemiologic studies suggest that hypoxia and infection are important risk factors. In this review we discuss the effect of hypoxia and platelet-activating factor (PAF) on intestinal blood flow and intestinal necrosis, and implicate PAF as an important mediator in hypoxia-induced intestinal injury. Finally we provide evidence that PAF may be important in neonatal NEC.

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Year:  1991        PMID： 1819729     DOI： 10.1007/BF02536562

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  41 in total

1.  Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor.

Authors:  X M Sun; W Hsueh
Journal:  J Clin Invest       Date:  1988-05       Impact factor: 14.808

2.  An experimental study of acute neonatal enterocolitis--the importance of breast milk.

Authors:  B Barlow; T V Santulli; W C Heird; J Pitt; W A Blanc; J N Schullinger
Journal:  J Pediatr Surg       Date:  1974-10       Impact factor: 2.545

3.  Role of oxygen derived free radicals in platelet activating factor induced bowel necrosis.

Authors:  J P Cueva; W Hsueh
Journal:  Gut       Date:  1988-09       Impact factor: 23.059

Review 4.  Necrotizing enterocolitis: a review of animal models.

Authors:  S L Topalian; M M Ziegler
Journal:  J Surg Res       Date:  1984-10       Impact factor: 2.192

5.  Pathogenesis of early necrotizing enterocolitis in the hypoxic neonatal dog.

Authors:  F Hansbrough; C J Priebe; K W Falterman; G H Bornside; R A Welsh
Journal:  Am J Surg       Date:  1983-01       Impact factor: 2.565

6.  The effect of hypoxia on rat splanchnic prostanoid output.

Authors:  M K Reed; B Taylor; S I Myers
Journal:  Prostaglandins       Date:  1989-11

7.  Pharmacological actions of WEB 2086, a new specific antagonist of platelet activating factor.

Authors:  J Casals-Stenzel; G Muacevic; K H Weber
Journal:  J Pharmacol Exp Ther       Date:  1987-06       Impact factor: 4.030

8.  Potent ulcerogenic actions of platelet-activating factor on the stomach.

Authors:  A C Rosam; J L Wallace; B J Whittle
Journal:  Nature       Date:  1986 Jan 2-8       Impact factor: 49.962

9.  Possible origins of PAF-acether and lyso-PAF-acether in rat lung alveoli secondary to hypoxia.

Authors:  M C Prévost; C Cariven; H Chap
Journal:  Biochim Biophys Acta       Date:  1988-10-14

10.  Comparison of the effect of asphyxia, hypoxia, and acidosis on intestinal blood flow and O2 uptake in newborn piglets.

Authors:  P Karna; A Senagore; C C Chou
Journal:  Pediatr Res       Date:  1986-10       Impact factor: 3.756
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  3 in total

Review 1.  Necrotizing enterocolitis: a practical guide to its prevention and management.

Authors:  Pinaki Panigrahi
Journal:  Paediatr Drugs       Date:  2006       Impact factor: 3.022

2.  Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells.

Authors:  Jing Lu; Michael S Caplan; Dan Li; Tamas Jilling
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2008-03-20       Impact factor: 4.052

Review 3.  The Role of Dietary Fats in the Development and Prevention of Necrotizing Enterocolitis.

Authors:  Belal N Alshaikh; Adriana Reyes Loredo; Megan Knauff; Sarfaraz Momin; Shirin Moossavi
Journal:  Nutrients       Date:  2021-12-29       Impact factor: 5.717
  3 in total

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