Chad A Hamilton1, Daniel S Kapp, John K Chan. 1. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Walter Reed Army Medical Center, Washington, District of Columbia, USA.
Abstract
PURPOSE OF REVIEW: We review the demographic and clinicopathologic characteristics, and prognosis of women diagnosed with uterine papillary serous carcinoma, with a focus on clinical management. RECENT FINDINGS: Pathologic evaluation of postmenopausal bleeding is preferred for patients who fit the profile of a high-risk endometrial cancer such as uterine papillary serous carcinoma. Women diagnosed with endometrial cancer who fit this profile and all women with uterine papillary serous carcinoma should undergo comprehensive surgical staging and aggressive cytoreduction of extrauterine disease. Adjuvant therapy remains controversial. Several recent investigations reported on the potential benefit of adjuvant chemotherapy, with many recommending additional loco-regional radiation. SUMMARY: Despite the lack of randomized trials on uterine papillary serous carcinoma, several recent reports have provided insight into the diagnosis, surgical management, and adjuvant treatment of this high-risk endometrial cancer.
PURPOSE OF REVIEW: We review the demographic and clinicopathologic characteristics, and prognosis of women diagnosed with uterine papillary serous carcinoma, with a focus on clinical management. RECENT FINDINGS: Pathologic evaluation of postmenopausal bleeding is preferred for patients who fit the profile of a high-risk endometrial cancer such as uterine papillary serous carcinoma. Women diagnosed with endometrial cancer who fit this profile and all women with uterine papillary serous carcinoma should undergo comprehensive surgical staging and aggressive cytoreduction of extrauterine disease. Adjuvant therapy remains controversial. Several recent investigations reported on the potential benefit of adjuvant chemotherapy, with many recommending additional loco-regional radiation. SUMMARY: Despite the lack of randomized trials on uterine papillary serous carcinoma, several recent reports have provided insight into the diagnosis, surgical management, and adjuvant treatment of this high-risk endometrial cancer.
Authors: Tao Jiang; Ning Chen; Fei Zhao; Xiao-Jun Wang; Beihua Kong; Wenxin Zheng; Donna D Zhang Journal: Cancer Res Date: 2010-06-08 Impact factor: 12.701
Authors: Mark H Einstein; Marina Frimer; Dennis Y-S Kuo; Laura L Reimers; Keyur Mehta; Subhakar Mutyala; Gloria S Huang; June Y Hou; Gary L Goldberg Journal: Gynecol Oncol Date: 2011-10-27 Impact factor: 5.482
Authors: Christopher J Walker; Mario A Miranda; Matthew J O'Hern; Joseph P McElroy; Kevin R Coombes; Ralf Bundschuh; David E Cohn; David G Mutch; Paul J Goodfellow Journal: J Natl Cancer Inst Date: 2015-09-01 Impact factor: 13.506
Authors: John K Chan; Stephanie Chow; Subasish Bhowmik; Amandeep Mann; Daniel S Kapp; Robert L Coleman Journal: Clin Exp Metastasis Date: 2018-06-21 Impact factor: 5.150
Authors: Manohar Pradhan; Ben Davidson; Vera Maria Abeler; Håvard Emil Danielsen; Claes Göran Tropé; Gunnar Balle Kristensen; Björn Åke Risberg Journal: Virchows Arch Date: 2012-07-24 Impact factor: 4.064
Authors: Giorgia Dinoi; Andrea Mariani; Enrica Martinelli; Alessandra Ciucci; Gian Franco Zannoni; Amy L Weaver; Gary L Keeney; George Vasmatzis; Panos Z Anastasiadis; Francesco Fanfani; Giovanni Scambia; Daniela Gallo Journal: J Cancer Res Clin Oncol Date: 2021-03-23 Impact factor: 4.553