| Literature DB >> 18195571 |
Yea-Lih Lin1, Clément Mettling, Pierre Portalès, Régine Rouzier, Jacques Clot, Jacques Reynes, Pierre Corbeau.
Abstract
The efficiency of CCR5 as an HIV coreceptor is strongly dependent on its level of cell surface expression. Therefore, it is of major importance to identify the factors that regulate cell surface density of CCR5. Among the chemokines that bind to CCR5, and induce its internalization, CCL5 is the most abundant in vivo. We show that the level of CCL5 production is a main factor determining CD4+ T cell surface CCR5 density.Entities:
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Year: 2008 PMID： 18195571 DOI： 10.1097/QAD.0b013e3282f46a6f
Source DB: PubMed Journal: AIDS ISSN： 0269-9370 Impact factor: 4.177