Literature DB >> 18195473

Triptolide inhibits CCR5 expressed in synovial tissue of rat adjuvant-induced arthritis.

Wang Yifan1, Wei Dengming, Lai Zheng, Le Yanping, Shen Junkan.   

Abstract

Triptolide has been clinically used to treat patients with rheumatoid arthritis, in which chemokine receptors play an important role in immune and inflammatory responses. To investigate the effect of triptolide on CCR5, we used complete Freund's adjuvant to produce adjuvant-induced arthritis (AIA) in rats. Our data show that both CCR5 mRNA and protein levels in synovial tissue of rats with AIA are significantly higher than those in normal rats. Triptolide can significantly inhibit rat AIA-induced overexpression of CCR5 at both mRNA and protein levels. These results may contribute to better understanding of the therapeutic effects of triptolide in rheumatoid arthritis.

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Year:  2007        PMID： 18195473

Source DB:  PubMed          Journal:  Pharmacol Rep        ISSN： 1734-1140            Impact factor:   3.024


  7 in total

1.  Norisoboldine alleviates joint destruction in rats with adjuvant-induced arthritis by reducing RANKL, IL-6, PGE(2), and MMP-13 expression.

Authors:  Zhi-feng Wei; Xiao-lan Jiao; Ting Wang; Qian Lu; Yu-feng Xia; Zheng-tao Wang; Qing-long Guo; Gui-xin Chou; Yue Dai
Journal:  Acta Pharmacol Sin       Date:  2013-02-11       Impact factor: 6.150

2.  Interleukin 6 inhibition by triptolide prevents inflammation in a mouse model of ulcerative colitis.

Authors:  Haifeng Zhang; Weichang Chen
Journal:  Exp Ther Med       Date:  2017-07-11       Impact factor: 2.447

3.  Tripterine ameliorates monosodium urate crystal-induced gouty arthritis by altering macrophage polarization via the miR-449a/NLRP3 axis.

Authors:  Yu Wang
Journal:  Inflamm Res       Date:  2021-02-09       Impact factor: 6.986

4.  WGCNA and molecular docking reveal key hub genes and potential natural inhibitor in interstitial cystitis/bladder pain syndrome.

Authors:  Kuiqing Li; Cong Lai; Cheng Liu; Zhuohang Li; Kaixuan Guo; Kewei Xu
Journal:  Int Urogynecol J       Date:  2022-03-25       Impact factor: 1.932

5.  Anti-angiogenic effect of triptolide in rheumatoid arthritis by targeting angiogenic cascade.

Authors:  Xiangying Kong; Yanqiong Zhang; Chunfang Liu; Wei Guo; Xiangbin Li; Xiaohui Su; Hongye Wan; Yanqun Sun; Na Lin
Journal:  PLoS One       Date:  2013-10-28       Impact factor: 3.240

6.  Triptolide Prevents Bone Destruction in the Collagen-Induced Arthritis Model of Rheumatoid Arthritis by Targeting RANKL/RANK/OPG Signal Pathway.

Authors:  Chunfang Liu; Yanqiong Zhang; Xiangying Kong; Liuluan Zhu; Jian Pang; Ying Xu; Weiheng Chen; Hongsheng Zhan; Aiping Lu; Na Lin
Journal:  Evid Based Complement Alternat Med       Date:  2013-03-12       Impact factor: 2.629

Review 7.  The Effect of Triptolide in Rheumatoid Arthritis: From Basic Research towards Clinical Translation.

Authors:  Danping Fan; Qingqing Guo; Jiawen Shen; Kang Zheng; Cheng Lu; Ge Zhang; Aiping Lu; Xiaojuan He
Journal:  Int J Mol Sci       Date:  2018-01-26       Impact factor: 5.923
  7 in total

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