| Literature DB >> 18194674 |
Agnieszka Jańczyk1, Agnieszka Wolnicka-Głubisz, Krystyna Urbanska, Horst Kisch, Grazyna Stochel, Wojciech Macyk.
Abstract
The visible light-induced phototoxicity of titanium dioxide modified with platinum(IV) chloride complexes, [TiO2/PtCl4], was tested. In vitro experiments with the mouse melanoma cells (S-91) have demonstrated phototoxicity of the [TiO2/PtCl4] material. Detection of efficiently generated various reactive oxygen species (.OH, O2. -, H2O2, 1O2) and also reactive chlorine species has proven the photodynamic activity of the tested material, induced by visible light (lambda>455 nm). The cellular death (recognized as a necrosis) is a result of the cell membrane peroxidation.Entities:
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Year: 2007 PMID： 18194674 DOI： 10.1016/j.freeradbiomed.2007.12.019
Source DB: PubMed Journal: Free Radic Biol Med ISSN： 0891-5849 Impact factor: 7.376