Literature DB >> 18193390

Biology-inspired synthesis of compound libraries.

M Kaiser1, S Wetzel, K Kumar, H Waldmann.   

Abstract

Biologically active small molecules represent the basis for chemical biology applications in which small molecules are used as chemical tools to probe biological processes. In this report, we review two approaches to design and synthesize compound libraries for biological screenings, i.e., diversity-oriented synthesis (DOS) and biology-oriented synthesis (BIOS).

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Year:  2008        PMID： 18193390     DOI： 10.1007/s00018-007-7492-1

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  31 in total

Review 1.  Virtual screening: an endless staircase?

Authors:  Gisbert Schneider
Journal:  Nat Rev Drug Discov       Date:  2010-04       Impact factor: 84.694

2.  Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.

Authors:  Warren R J D Galloway; Albert Isidro-Llobet; David R Spring
Journal:  Nat Commun       Date:  2010-09-21       Impact factor: 14.919

3.  Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds.

Authors:  Brett A Granger; Kyosuke Kaneda; Stephen F Martin
Journal:  Org Lett       Date:  2011-08-11       Impact factor: 6.005

4.  Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products.

Authors:  Andrey P Antonchick; Claas Gerding-Reimers; Mario Catarinella; Markus Schürmann; Hans Preut; Slava Ziegler; Daniel Rauh; Herbert Waldmann
Journal:  Nat Chem       Date:  2010-07-11       Impact factor: 24.427

5.  Bioactivity-guided mapping and navigation of chemical space.

Authors:  Steffen Renner; Willem A L van Otterlo; Marta Dominguez Seoane; Sabine Möcklinghoff; Bettina Hofmann; Stefan Wetzel; Ansgar Schuffenhauer; Peter Ertl; Tudor I Oprea; Dieter Steinhilber; Luc Brunsveld; Daniel Rauh; Herbert Waldmann
Journal:  Nat Chem Biol       Date:  2009-06-28       Impact factor: 15.040

Review 6.  Neurobiological applications of small molecule screening.

Authors:  Andras Bauer; Brent Stockwell
Journal:  Chem Rev       Date:  2008-05-01       Impact factor: 60.622

7.  Diversity-oriented synthesis of macrocyclic peptidomimetics.

Authors:  Albert Isidro-Llobet; Tiffanie Murillo; Paula Bello; Agostino Cilibrizzi; James T Hodgkinson; Warren R J D Galloway; Andreas Bender; Martin Welch; David R Spring
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-07       Impact factor: 11.205

Review 8.  UDP-sugar pyrophosphorylase: a new old mechanism for sugar activation.

Authors:  Leszek A Kleczkowski; Daniel Decker; Malgorzata Wilczynska
Journal:  Plant Physiol       Date:  2011-03-28       Impact factor: 8.340

9.  Natural-product-derived fragments for fragment-based ligand discovery.

Authors:  Björn Over; Stefan Wetzel; Christian Grütter; Yasushi Nakai; Steffen Renner; Daniel Rauh; Herbert Waldmann
Journal:  Nat Chem       Date:  2012-12-02       Impact factor: 24.427

10.  A chemical screen for suppressors of the avrRpm1-RPM1-dependent hypersensitive cell death response in Arabidopsis thaliana.

Authors:  Mario Serrano; David A Hubert; Jeffery L Dangl; Paul Schulze-Lefert; Erich Kombrink
Journal:  Planta       Date:  2010-02-07       Impact factor: 4.116
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