Literature DB >> 18193262

Orbital invasion despite topical anti-metabolite therapy for conjunctival carcinoma.

Devron H Char1, J Brooks Crawford.   

Abstract

BACKGROUND: Two cases of conjunctival carcinoma developed orbital invasion during treatment with topical medication.
METHODS: This was a retrospective study from a tertiary ophthalmic oncology unit, performed after informed consent was obtained. The main outcome measurement was orbital invasion.
RESULTS: Two patients treated with topical agents developed orbital invasion.
CONCLUSION: While topical agents are important in treatment of conjunctival neoplasia, recurrence or deep invasion require careful monitoring.

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Year:  2008        PMID: 18193262     DOI: 10.1007/s00417-007-0742-y

Source DB:  PubMed          Journal:  Graefes Arch Clin Exp Ophthalmol        ISSN: 0721-832X            Impact factor:   3.117


  8 in total

Review 1.  Role of topical chemotherapy for primary acquired melanosis and malignant melanoma of the conjunctiva and cornea: review of the evidence and recommendations for treatment.

Authors:  Rajeev Chalasani; Michael Giblin; R Max Conway
Journal:  Clin Exp Ophthalmol       Date:  2006 Sep-Oct       Impact factor: 4.207

2.  Eyelid melanoma with negative sentinel lymph node biopsy and perineural spread.

Authors:  Mary E Turell; Devron H Char
Journal:  Arch Ophthalmol       Date:  2007-07

Review 3.  Topical medical therapies for ocular surface tumors.

Authors:  Antony M Poothullil; Kathryn A Colby
Journal:  Semin Ophthalmol       Date:  2006 Jul-Sep       Impact factor: 1.975

4.  Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: clinical experience with histopathologic observations.

Authors:  H Demirci; S A McCormick; P T Finger
Journal:  Arch Ophthalmol       Date:  2000-07

5.  Topical 5-fluorouracil in treating epithelial neoplasia of the conjunctiva and cornea.

Authors:  R P Yeatts; J G Ford; C A Stanton; J W Reed
Journal:  Ophthalmology       Date:  1995-09       Impact factor: 12.079

6.  Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia.

Authors:  J J Khong; J Muecke
Journal:  Br J Ophthalmol       Date:  2006-05-03       Impact factor: 4.638

7.  Current treatment options for conjunctival and corneal intraepithelial neoplasia.

Authors:  Joann A Giaconi; Carol L Karp
Journal:  Ocul Surf       Date:  2003-04       Impact factor: 5.033

8.  Topical application of 5-fluorouracil in premalignant lesions of cornea, conjunctiva and eyelid.

Authors:  R J de Keizer; D de Wolff-Rouendaal; J L van Delft
Journal:  Doc Ophthalmol       Date:  1986-12-30       Impact factor: 2.379

  8 in total

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