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Literature DB >> 18193164

Structures of thrombospondins.

Abstract

Thrombospondins are large secreted, multimodular, calcium-binding glycoproteins that have complex roles in mediating cellular processes. Determination of high-resolution structures of thrombospondins has revealed unique and interesting protein motifs. Here, we review this progress and discuss implications for function. By combining structures of modules from thrombospondins and related extracellular proteins it is now possible to prepare an overall model of the structure of thrombospondin-1 and thrombospondin-2 and discern features of other thrombospondins. (Part of a multi-author Review).

Entities: Gene

Mesh：

Substances：
Thrombospondins

Year: 2008 PMID： 18193164 PMCID： PMC2578829 DOI： 10.1007/s00018-007-7484-1

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

58 in total

Review 1. The cell biology of thrombospondin-1.

Authors: H Chen; M E Herndon; J Lawler
Journal: Matrix Biol Date: 2000-12 Impact factor: 11.583

2. Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes.

Authors: H Chen; M Deere; J T Hecht; J Lawler
Journal: J Biol Chem Date: 2000-08-25 Impact factor: 5.157

3. Calreticulin, PDI, Grp94 and BiP chaperone proteins are associated with retained COMP in pseudoachondroplasia chondrocytes.

Authors: J T Hecht; E Hayes; M Snuggs; G Decker; D Montufar-Solis; K Doege; F Mwalle; R Poole; J Stevens; P J Duke
Journal: Matrix Biol Date: 2001-07 Impact factor: 11.583

4. Selective intracellular retention of extracellular matrix proteins and chaperones associated with pseudoachondroplasia.

Authors: J Vranka; A Mokashi; D R Keene; S Tufa; G Corson; M Sussman; W A Horton; K Maddox; L Sakai; H P Bächinger
Journal: Matrix Biol Date: 2001-11 Impact factor: 11.583

5. C-mannosylation and O-fucosylation of the thrombospondin type 1 module.

Authors: J Hofsteenge; K G Huwiler; B Macek; D Hess; J Lawler; D F Mosher; J Peter-Katalinic
Journal: J Biol Chem Date: 2000-11-06 Impact factor: 5.157

6. Cartilage oligomeric matrix protein interacts with type IX collagen, and disruptions to these interactions identify a pathogenetic mechanism in a bone dysplasia family.

Authors: P Holden; R S Meadows; K L Chapman; M E Grant; K E Kadler; M D Briggs
Journal: J Biol Chem Date: 2000-11-21 Impact factor: 5.157

7. Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX.

Authors: J Thur; K Rosenberg; D P Nitsche; T Pihlajamaa; L Ala-Kokko; D Heinegård; M Paulsson; P Maurer
Journal: J Biol Chem Date: 2000-11-17 Impact factor: 5.157

8. Physical characterization of the procollagen module of human thrombospondin 1 expressed in insect cells.

Authors: T M Misenheimer; K G Huwiler; D S Annis; D F Mosher
Journal: J Biol Chem Date: 2000-12-29 Impact factor: 5.157

9. A phase II study of ABT-510 (thrombospondin-1 analog) for the treatment of metastatic melanoma.

Authors: Svetomir N Markovic; Vera J Suman; Ravi A Rao; James N Ingle; Judith S Kaur; Lori A Erickson; Henry C Pitot; Gary A Croghan; Robert R McWilliams; Jaime Merchan; Lisa A Kottschade; Wendy K Nevala; Cindy B Uhl; Jacob Allred; Edward T Creagan
Journal: Am J Clin Oncol Date: 2007-06 Impact factor: 2.339

10. Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations.

Authors: Douglas S Annis; Kristin A Gunderson; Deane F Mosher
Journal: J Biol Chem Date: 2007-07-09 Impact factor: 5.157

88 in total

1. Platelet activation, P-selectin, and eosinophil β1-integrin activation in asthma.

Authors: Mats W Johansson; Shih-Tsung Han; Kristin A Gunderson; William W Busse; Nizar N Jarjour; Deane F Mosher
Journal: Am J Respir Crit Care Med Date: 2012-01-06 Impact factor: 21.405

Review 2. The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47.

Authors: David D Roberts; Thomas W Miller; Natasha M Rogers; Mingyi Yao; Jeffrey S Isenberg
Journal: Matrix Biol Date: 2012-01-14 Impact factor: 11.583

3. Emerging functions of matricellular proteins.

Authors: David D Roberts
Journal: Cell Mol Life Sci Date: 2011-08-11 Impact factor: 9.261

4. The calreticulin-binding sequence of thrombospondin 1 regulates collagen expression and organization during tissue remodeling.

Authors: Mariya T Sweetwyne; Manuel A Pallero; Ailing Lu; Lauren Van Duyn Graham; Joanne E Murphy-Ullrich
Journal: Am J Pathol Date: 2010-08-19 Impact factor: 4.307

5. Ribozyme-mediated reduction of wild-type and mutant cartilage oligomeric matrix protein (COMP) mRNA and protein.

Authors: Joseph L Alcorn; Thomas M Merritt; Mary C Farach-Carson; Huiqui H Wang; Jacqueline T Hecht
Journal: RNA Date: 2009-02-23 Impact factor: 4.942

Review 6. The counteradhesive proteins, thrombospondin 1 and SPARC/osteonectin, open the tyrosine phosphorylation-responsive paracellular pathway in pulmonary vascular endothelia.

Authors: Anguo Liu; Deane F Mosher; Joanne E Murphy-Ullrich; Simeon E Goldblum
Journal: Microvasc Res Date: 2008-10-01 Impact factor: 3.514

7. Thrombospondin expression in myofibers stabilizes muscle membranes.

Authors: Davy Vanhoutte; Tobias G Schips; Jennifer Q Kwong; Jennifer Davis; Andoria Tjondrokoesoemo; Matthew J Brody; Michelle A Sargent; Onur Kanisicak; Hong Yi; Quan Q Gao; Joseph E Rabinowitz; Talila Volk; Elizabeth M McNally; Jeffery D Molkentin
Journal: Elife Date: 2016-09-26 Impact factor: 8.140