| Literature DB >> 18193016 |
Nicholas E Leadbeater1, Jason R Schmink.
Abstract
The progress of microwave-promoted reactions can be monitored by interfacing a Raman spectrometer with a scientific microwave unit. The apparatus is assembled from commercially available components. It is used in this protocol to follow the base-catalyzed reaction of salicylaldehyde with ethylacetoacetate to yield 3-acetylcoumarin. It is possible to watch the reaction spectroscopically in real time, determine when it reaches completion and thus use it as a tool for rapid reaction optimization.Entities:
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Year: 2008 PMID： 18193016 DOI： 10.1038/nprot.2007.453
Source DB: PubMed Journal: Nat Protoc ISSN： 1750-2799 Impact factor: 13.491