| Literature DB >> 1819218 |
A Modesto1, L Marty, J M Suc, D Kleinknecht, J F de Frémont, T Marsepoil, P Veyssier.
Abstract
We report 3 patients who developed signs of systemic infection and renal insufficiency after intravesical bacillus Calmette-Guérin (BCG) instillations for a bladder cancer. Renal biopsy showed tubulo-interstitial nephritis with or without epithelioid granulomas in 2 cases, and mesangial glomerulonephritis in the last case. All patients had granulomatous hepatitis in association. It seems that hematogenous dissemination via a traumatic instillation of BCG and/or an immune-complex mechanism may have contributed to the renal damage, which was only partially reversible in 2 patients.Entities:
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Year: 1991 PMID: 1819218 DOI: 10.1159/000168368
Source DB: PubMed Journal: Am J Nephrol ISSN: 0250-8095 Impact factor: 3.754