OBJECTIVES: Determination of the prooxidant-antioxidant balance (PAB) in patients with angiographically defined coronary artery disease (CAD+) by a modified PAB assay and presentation of PAB value as a novel cardiovascular risk factor. DESIGN AND METHODS: For 61 patients with CAD+ and 63 healthy volunteers, the PAB were measured and its correlation was determined with anthropological and clinical parameters. RESULTS: A significant increase of the PAB value was observed in patients in comparison to control group. A correlation, which is not quite significant, was noted between angiographic finding (number of diseased vessel) and the PAB values in patients. A significant positive correlation was established between the PAB value and systolic blood pressure, diastolic blood pressure, smoking, fasting blood sugar and serum urea concentration; and a significant negative correlation was established between PAB value and serum creatinine and bilirubin. CONCLUSIONS: This study shows that the PAB value may be considered as a cardiovascular risk factor. Further clinical research is needed to substantiate the potency of the PAB value as a cardiovascular risk factor.
OBJECTIVES: Determination of the prooxidant-antioxidant balance (PAB) in patients with angiographically defined coronary artery disease (CAD+) by a modified PAB assay and presentation of PAB value as a novel cardiovascular risk factor. DESIGN AND METHODS: For 61 patients with CAD+ and 63 healthy volunteers, the PAB were measured and its correlation was determined with anthropological and clinical parameters. RESULTS: A significant increase of the PAB value was observed in patients in comparison to control group. A correlation, which is not quite significant, was noted between angiographic finding (number of diseased vessel) and the PAB values in patients. A significant positive correlation was established between the PAB value and systolic blood pressure, diastolic blood pressure, smoking, fasting blood sugar and serum urea concentration; and a significant negative correlation was established between PAB value and serum creatinine and bilirubin. CONCLUSIONS: This study shows that the PAB value may be considered as a cardiovascular risk factor. Further clinical research is needed to substantiate the potency of the PAB value as a cardiovascular risk factor.
Authors: Seyyed M R Parizadeh; Mahmoud R Azarpazhooh; Mohsen Moohebati; Mohsen Nematy; Majid Ghayour-Mobarhan; Shima Tavallaie; Amir A Rahsepar; Maral Amini; Amirhossein Sahebkar; Maryam Mohammadi; Gordon A A Ferns Journal: Lipids Date: 2011-01-05 Impact factor: 1.880
Authors: Efstathios T Pavlidis; Konstantinos D Ballas; Nikolaos G Symeonidis; Kyriakos Psarras; Georgios Koliakos; Kokona Kouzi-Koliakos; Konstantina Topouridou; Savas F Rafailidis; Theodoros E Pavlidis; Georgios N Marakis; Athanasios K Sakantamis Journal: Int J Colorectal Dis Date: 2010-08-06 Impact factor: 2.571
Authors: George G Koliakos; Christina D Befani; Dimitrios Mikropoulos; Nikolaos G Ziakas; Anastasios G P Konstas Journal: Graefes Arch Clin Exp Ophthalmol Date: 2008-07-08 Impact factor: 3.117