| Literature DB >> 18191402 |
Nora Benaamane1, Bellara Nedjar-Kolli, Yamina Bentarzi, Lamouri Hammal, Athina Geronikaki, Phaedra Eleftheriou, Alexey Lagunin.
Abstract
Cyclisation of pyrazolo-beta-enaminones 3 readily obtained from 4-aceto acetyl pyrazol 2 with triphosgene led to the formation of N-substituted pyrazolo-1,3-oxazin-2-ones 4 in good yields. Estimation of pharmacotherapeutic potential, possible molecule mechanisms of action, toxic/side effects and interaction with drug-metabolizing enzymes were made for synthesised compounds on the basis of prediction of activity spectra for substances (PASS) prediction results and their analysis by PharmaExpert software. COX inhibition predicted by PASS was confirmed by experimental evaluation.Entities:
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Year: 2007 PMID： 18191402 DOI： 10.1016/j.bmc.2007.12.033
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641