| Literature DB >> 18191233 |
Silvia Ratto-Kim1, Thippawan Chuenchitra, Lynn Pulliam, Robert Paris, Suchitra Sukwit, Siriphan Gongwon, Pasiri Sithinamsuwan, Samart Nidhinandana, Sataporn Thitivichianlert, Bruce T Shiramizu, Mark S de Souza, Suwicha T Chitpatima, Bing Sun, Hans Rempel, Sorachai Nitayaphan, Kenneth Williams, Jerome H Kim, Cecilia M Shikuma, Victor G Valcour.
Abstract
HIV Associated Dementia (HAD) is a complication of HIV infection in developed countries and is still poorly defined in resource-limited settings. In this study we investigated the expression of the monocyte phenotype CD14CD16HLADR and the inflammatory profiles in monocytes supernatants by surface-enhanced laser desorption/ionization-time of flight (SELDI-TOF) mass spectrometry in a cohort of HAD and non-HAD Thai volunteers prior to the initiation of ARV. The CD14CD16HLADR phenotype was significantly increased in monocytes from HAD and non-HAD versus negative controls, but there was no difference in phenotype and in the secretion protein profiles between the two seropositive groups. In addition, monocytes supernatants from HAD and non-HAD did not induced apoptosis or cell death in brain aggregate culture. In conclusion it appears that HAD in Thai individuals has a different immunological profile then in North America cohorts.Entities:
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Year: 2008 PMID： 18191233 PMCID： PMC3670943 DOI： 10.1016/j.jneuroim.2007.11.021
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478