| Literature DB >> 18190394 |
Hisamitsu Ide1, Kiyohiko Hatake, Yuichi Terado, Hiroyuki Tsukino, Takatsugu Okegawa, Kikuo Nutahara, Eiji Higashihara, Shigeo Horie.
Abstract
Recent evaluation of human prostate tissues has shown predominantly high expression of the macrophage colony-stimulating factor receptor in prostatic intra-epithelial neoplasia or prostate cancer. However, the expression of its ligand, the macrophage colony-stimulating factor (M-CSF), and the biological role of this signaling in prostate cancer has not been analyzed. In this research we determined the relationship of serum M-CSF level to clinical parameters of prostate cancer progression. We measured the serum level of M-CSF in 170 patients with histologically confirmed prostatic adenocarcinoma and in 54 patients in whom prostate cancer was not detected. We also investigated the M-CSF expression in prostate cancer tissues by immunohistochemistry. The serum levels of M-CSF in bone metastatic prostate cancer patients was significantly higher than those in non-metastatic patients, while M-CSF did not differ with regards to histological grade, Gleason score or local tumor progression. M-CSF expression was detected in prostate cancer cells themselves by immunohistochemistry. These results suggest that M-CSF may have a functional role in prostate cancer progression.Entities:
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Year: 2008 PMID： 18190394 DOI： 10.1111/j.1749-0774.2007.00042.x
Source DB: PubMed Journal: Hum Cell ISSN： 0914-7470 Impact factor: 4.174