OBJECTIVE: To assess maternal cardiac function in nulliparous women in the first trimester of pregnancy and evaluate its potential role for predicting pre-eclampsia and small for gestational age (SGA). DESIGN: Prospective, observational, cross-sectional study. SETTING: Maternity unit of a teaching hospital. POPULATION: Nulliparous women with singleton pregnancies presenting consecutively for routine antenatal care (n= 534). METHODS: Two-dimensional and M-mode echocardiography and uterine artery Dopplers were carried out at 11-14 weeks. MAIN OUTCOME MEASURES: Cardiac output (CO), stroke volume (SV), mean arterial pressure (MAP), total vascular resistance and uterine artery pulsatility index (UAPI) were compared in four outcome groups according to the development of pre-eclampsia and/or SGA. RESULTS: Compared with the normal outcome group (n= 457), in those with pre-eclampsia but not SGA (n = 8), CO and MAP were increased; in the group with pre-eclampsia and SGA (n= 19) MAP, TRP and UAPI were increased and in the group with SGA but no pre-eclampsia (n= 50) total peripheral resistance and UAPI were increased. Independent predictors of pre-eclampsia were MAP, SV and UAPI and of SGA SV and UAPI. CONCLUSIONS: Alterations in maternal cardiac function and UAPI are observed in the first trimester of pregnancy in nulliparous women that subsequently develop pre-eclampsia and/or SGA.
OBJECTIVE: To assess maternal cardiac function in nulliparous women in the first trimester of pregnancy and evaluate its potential role for predicting pre-eclampsia and small for gestational age (SGA). DESIGN: Prospective, observational, cross-sectional study. SETTING: Maternity unit of a teaching hospital. POPULATION: Nulliparous women with singleton pregnancies presenting consecutively for routine antenatal care (n= 534). METHODS: Two-dimensional and M-mode echocardiography and uterine artery Dopplers were carried out at 11-14 weeks. MAIN OUTCOME MEASURES: Cardiac output (CO), stroke volume (SV), mean arterial pressure (MAP), total vascular resistance and uterine artery pulsatility index (UAPI) were compared in four outcome groups according to the development of pre-eclampsia and/or SGA. RESULTS: Compared with the normal outcome group (n= 457), in those with pre-eclampsia but not SGA (n = 8), CO and MAP were increased; in the group with pre-eclampsia and SGA (n= 19) MAP, TRP and UAPI were increased and in the group with SGA but no pre-eclampsia (n= 50) total peripheral resistance and UAPI were increased. Independent predictors of pre-eclampsia were MAP, SV and UAPI and of SGA SV and UAPI. CONCLUSIONS: Alterations in maternal cardiac function and UAPI are observed in the first trimester of pregnancy in nulliparous women that subsequently develop pre-eclampsia and/or SGA.
Authors: Kirk P Conrad; John W Petersen; Yueh-Yun Chi; Xiaoman Zhai; Minjie Li; Kuei-Hsun Chiu; Jing Liu; Melissa D Lingis; R Stan Williams; Alice Rhoton-Vlasak; Joseph J Larocca; Wilmer W Nichols; Mark S Segal Journal: Hypertension Date: 2019-07-29 Impact factor: 10.190
Authors: Sarah Hale; Martha Choate; Adrienne Schonberg; Robert Shapiro; Gary Badger; Ira M Bernstein Journal: Reprod Sci Date: 2010-07-16 Impact factor: 3.060
Authors: Seung Mi Lee; Jong Kwan Jun; Su Jin Sung; Sung Il Choo; Jeong Yeon Cho; Hye Jin Yang; Chan-Wook Park; Joong Shin Park; Hee Chul Syn Journal: Obstet Gynecol Sci Date: 2016-11-15