Literature DB >> 18190263

A pneumococcal MerR-like regulator and S-nitrosoglutathione reductase are required for systemic virulence.

Uwe H Stroeher1, Stephen P Kidd, Sian L Stafford, Michael P Jennings, James C Paton, Alastair G McEwan.   

Abstract

A transcriptional regulator, NmlR(sp), has been identified in Streptococcus pneumoniae that is required for defense against nitric oxide (NO) stress. The nmlR(sp) gene is cotranscribed with adhC, which encodes an alcohol dehydrogenase that is able to reduce S-nitrosoglutathione (GSNO) with NADH as reductant. nmlR(sp) and adhC mutants exhibited a reduced level of NADH-GSNO oxidoreductase activity and were more susceptible to killing by NO than were wild-type cells. Comparison of the virulence of wild-type and mutant strains by use of a mouse model system showed that NmlR(sp) and AdhC do not play a key role in the adherence of pneumococci to the nasopharynx in vivo. An intraperitoneal challenge experiment revealed that both NmlR(sp) and AdhC were required for survival in blood. These data identify novel components of a NO defense system in pneumococci that are required for systemic infection.

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Year:  2007        PMID： 18190263     DOI： 10.1086/523107

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  24 in total

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Review 2.  Protein denitrosylation: enzymatic mechanisms and cellular functions.

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Review 4.  Thiol-based redox switches and gene regulation.

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5.  The MerR/NmlR family transcription factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production.

Authors:  Adam J Potter; Stephen P Kidd; Alastair G McEwan; James C Paton
Journal:  J Bacteriol       Date:  2010-06-04       Impact factor: 3.490

6.  Conversion of S-phenylsulfonylcysteine residues to mixed disulfides at pH 4.0: utility in protein thiol blocking and in protein-S-nitrosothiol detection.

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Journal:  Org Biomol Chem       Date:  2014-07-02       Impact factor: 3.876

7.  S-nitrosomycothiol reductase and mycothiol are required for survival under aldehyde stress and biofilm formation in Mycobacterium smegmatis.

Authors:  Derek Vargas; Samantha Hageman; Megha Gulati; Clarissa J Nobile; Mamta Rawat
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8.  A protein microarray-based analysis of S-nitrosylation.

Authors:  Matthew W Foster; Michael T Forrester; Jonathan S Stamler
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-28       Impact factor: 11.205

9.  Glutathione-dependent alcohol dehydrogenase AdhC is required for defense against nitrosative stress in Haemophilus influenzae.

Authors:  Stephen P Kidd; Donald Jiang; Michael P Jennings; Alastair G McEwan
Journal:  Infect Immun       Date:  2007-06-25       Impact factor: 3.441

10.  Role of the manganese efflux system mntE for signalling and pathogenesis in Streptococcus pneumoniae.

Authors:  Jason W Rosch; Geli Gao; Granger Ridout; Yong-Dong Wang; Elaine I Tuomanen
Journal:  Mol Microbiol       Date:  2009-02-17       Impact factor: 3.501
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