Literature DB >> 18189411

Ti-catalyzed reformatsky-type coupling between alpha-halo ketones and aldehydes.

Rosa E Estévez1, Miguel Paradas, Alba Millan, Tania Jiménez, Rafael Robles, Juan M Cuerva, J Enrique Oltra.   

Abstract

We describe the first Ti-catalyzed Reformatsky-type coupling between alpha-halo ketones and aldehydes. The reaction affords beta-hydroxy ketones under mild, neutral conditions compatible with ketones and other electrophiles. The catalytic cycle possibly proceeds via bis(cyclopentadienyl)titanium enolates.

Entities:  

Year:  2008        PMID： 18189411     DOI： 10.1021/jo702189k

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

1.  Tandem application of C-C bond-forming reactions with reductive ozonolysis.

Authors:  Rachel Willand-Charnley; Patrick H Dussault
Journal:  J Org Chem       Date:  2012-10-02       Impact factor: 4.354

2.  Titanium Radical Redox Catalysis: Recent Innovations in Catalysts, Reactions, and Modes of Activation.

Authors:  Xiangyu Wu; Yejin Chang; Song Lin
Journal:  Chem       Date:  2022-07-01       Impact factor: 25.832

3.  Towards the Total Synthesis of Pl-3: Preparation of the Eastern Fragment through a Diastereoselective SmI2-Mediated Reformatsky Reaction.

Authors:  Rita Fürst; Christoph Lentsch; Uwe Rinner
Journal:  European J Org Chem       Date:  2013-03-07
  3 in total

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