Literature DB >> 18189407

Click-connected ligand scaffolds: macrocyclic chelates for asymmetric hydrogenation.

Qing Zhang1, James M Takacs.   

Abstract

Click chemistry is used to construct ligand scaffolds for a series of chiral diphosphites. Enantioselectivity as high as 97% ee is obtained using these click ligands in rhodium-catalyzed asymmetric hydrogenation. Control experiments and spectroscopic data suggest that a 16-membered P,P-macrocyclic Rh(I) chelate is formed.

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Year:  2008        PMID： 18189407     DOI： 10.1021/ol702890s

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

1.  Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein.

Authors:  Bhargav A Patel; Biebele Abel; Anna Maria Barbuti; Uday Kiran Velagapudi; Zhe-Sheng Chen; Suresh V Ambudkar; Tanaji T Talele
Journal:  J Med Chem       Date:  2018-01-23       Impact factor: 7.446

2.  Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents.

Authors:  Julia Fernández de Luco; Alejandro I Recio-Balsells; Diego G Ghiano; Ana Bortolotti; Juán Manuel Belardinelli; Nina Liu; Pascal Hoffmann; Christian Lherbet; Peter J Tonge; Babu Tekwani; Héctor R Morbidoni; Guillermo R Labadie
Journal:  RSC Med Chem       Date:  2020-11-05

3.  Ligand scaffold optimization of a supramolecular hydrogenation catalyst: Analyzing the influence of key structural subunits on reactivity and selectivity.

Authors:  Nathan C Thacker; Shin A Moteki; James M Takacs
Journal:  ACS Catal       Date:  2012-11-05       Impact factor: 13.084

4.  A Convenient Reagent for Aldehyde to Alkyne Homologation.

Authors:  Douglass F Taber; Sha Bai; Peng-Fei Guo
Journal:  Tetrahedron Lett       Date:  2008-11-24       Impact factor: 2.415

5.  Synthesis and properties of chiral thioureas bearing an additional function at a remote position tethered by a 1,5-disubstituted triazole.

Authors:  Kiyosei Takasu; Takumi Azuma; Iderbat Enkhtaivan; Yoshiji Takemoto
Journal:  Molecules       Date:  2010-11-15       Impact factor: 4.411

6.  The search for new amphiphiles: synthesis of a modular, high-throughput library.

Authors:  George C Feast; Thomas Lepitre; Xavier Mulet; Charlotte E Conn; Oliver E Hutt; G Paul Savage; Calum J Drummond
Journal:  Beilstein J Org Chem       Date:  2014-07-10       Impact factor: 2.883

7.  Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells.

Authors:  Benjamin E Alexander; Sijia Sun; Matthew J Palframan; Gabriele Kociok-Köhn; Dya Fita Dibwe; Shiro Watanabe; Lorenzo Caggiano; Suresh Awale; Simon E Lewis
Journal:  ChemMedChem       Date:  2019-12-10       Impact factor: 3.466
  7 in total

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