BACKGROUND: The study and assessment of oxidative stress plays a significant role in the arena of leprosy treatment. Once the presence of oxidative stress is proved, antioxidant supplements can be provided to reduce tissue injury and deformity. AIM: To study oxidative stress in paucibacillary (PB) and multibacillary (MB) leprosy and to compare it with that in a control group. METHODS: Fifty-eight untreated leprosy patients (23 PB and 35 MB cases) were studied and compared with 58 healthy controls. Superoxide dismutase (SOD) level as a measure of antioxidant status; malondialdehyde (MDA)level, an indicator of lipid peroxidation; and MDA/SOD ratio, an index of oxidative stress were estimated in the serum. RESULTS: The SOD level was decreased in leprosy patients, especially in MB leprosy. The MDA level was increased in PB and MB leprosy. The MDA/SOD ratio was significantly elevated in MB patients. There was a steady increase in this ratio along the spectrum from tuberculoid to lepromatous leprosy (LL). CONCLUSION: There is increased oxidative stress in MB leprosy, especially in LL. This warrants antioxidant supplements to prevent tissue injury.
BACKGROUND: The study and assessment of oxidative stress plays a significant role in the arena of leprosy treatment. Once the presence of oxidative stress is proved, antioxidant supplements can be provided to reduce tissue injury and deformity. AIM: To study oxidative stress in paucibacillary (PB) and multibacillary (MB) leprosy and to compare it with that in a control group. METHODS: Fifty-eight untreated leprosypatients (23 PB and 35 MB cases) were studied and compared with 58 healthy controls. Superoxide dismutase (SOD) level as a measure of antioxidant status; malondialdehyde (MDA)level, an indicator of lipid peroxidation; and MDA/SOD ratio, an index of oxidative stress were estimated in the serum. RESULTS: The SOD level was decreased in leprosypatients, especially in MB leprosy. The MDA level was increased in PB and MB leprosy. The MDA/SOD ratio was significantly elevated in MB patients. There was a steady increase in this ratio along the spectrum from tuberculoid to lepromatous leprosy (LL). CONCLUSION: There is increased oxidative stress in MB leprosy, especially in LL. This warrants antioxidant supplements to prevent tissue injury.
Authors: Yvelise T Morato-Conceicao; Eduardo R Alves-Junior; Talita A Arruda; Jose C Lopes; Cor J F Fontes Journal: PeerJ Date: 2016-03-14 Impact factor: 2.984
Authors: Veronica Schmitz; Isabella Forasteiro Tavares; Patricia Pignataro; Alice de Miranda Machado; Fabiana Dos Santos Pacheco; Jéssica Brandão Dos Santos; Camila Oliveira da Silva; Euzenir Nunes Sarno Journal: Front Immunol Date: 2019-03-19 Impact factor: 7.561
Authors: Julio J Amaral; Luis Caetano M Antunes; Cristiana S de Macedo; Katherine A Mattos; Jun Han; Jingxi Pan; André L P Candéa; Maria das Graças M O Henriques; Marcelo Ribeiro-Alves; Christoph H Borchers; Euzenir N Sarno; Patrícia T Bozza; B Brett Finlay; Maria Cristina V Pessolani Journal: PLoS Negl Trop Dis Date: 2013-08-15