Literature DB >> 18187235

Linking cerebrovascular defense mechanisms in brain ageing and Alzheimer's disease.

Raj N Kalaria.   

Abstract

Apart from the cardiovascular system, several cerebrovascular defense mechanisms inherently function to maintain homeostasis of the neurovascular unit. Prevailing evidence suggests that cerebrovascular functions decline differentially during normal ageing with pronounced effects in Alzheimer's disease (AD). This commentary highlights how vascular regulatory mechanisms may change with age and precede disease to explain the interesting links between changes in the cerebral endothelium, cerebral blood flow (CBF) and functional hyperemia during ageing that are already apparent in AD.

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Year:  2008        PMID： 18187235     DOI： 10.1016/j.neurobiolaging.2007.10.020

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  20 in total

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