Literature DB >> 18185517

Is cell competition relevant to cancer?

Eduardo Moreno1.   

Abstract

Cell competition is a type of short-range cell-cell interaction described in Drosophila melanogaster, in which cells expressing different levels of a particular protein are able to discriminate between their relative levels of that protein in such a way that one of the cells disappears from the tissue (the loser), whereas the other (the winner) not only survives but also proliferates to fill the space left by the disappearing cells. Some tumour-promoting mutations are able to induce cell competition in D. melanogaster, but could cell competition become a target for therapeutic intervention, or early detection, in human cancer?

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Year:  2008        PMID: 18185517     DOI: 10.1038/nrc2252

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN: 1474-175X            Impact factor:   60.716


  75 in total

Review 1.  c-Myc induction of programmed cell death may contribute to carcinogenesis: a perspective inspired by several concepts of chemical carcinogenesis.

Authors:  Chenguang Wang; Yanhong Tai; Michael P Lisanti; D Joshua Liao
Journal:  Cancer Biol Ther       Date:  2011-04-01       Impact factor: 4.742

Review 2.  Cell competition and its implications for development and cancer.

Authors:  Yoichiro Tamori; Wu-Min Deng
Journal:  J Genet Genomics       Date:  2011-09-21       Impact factor: 4.275

3.  Myc Function in Drosophila.

Authors:  Paola Bellosta; Peter Gallant
Journal:  Genes Cancer       Date:  2010-06-01

Review 4.  Somatic mosaicism: on the road to cancer.

Authors:  Luis C Fernández; Miguel Torres; Francisco X Real
Journal:  Nat Rev Cancer       Date:  2015-12-18       Impact factor: 60.716

5.  Ribosomal Protein S12e Has a Distinct Function in Cell Competition.

Authors:  Abhijit Kale; Zhejun Ji; Marianthi Kiparaki; Jorge Blanco; Gerard Rimesso; Stephane Flibotte; Nicholas E Baker
Journal:  Dev Cell       Date:  2018-01-08       Impact factor: 12.270

Review 6.  Tissue-Intrinsic Tumor Hotspots: Terroir for Tumorigenesis.

Authors:  Yoichiro Tamori; Wu-Min Deng
Journal:  Trends Cancer       Date:  2017-04-04

7.  When flies and mice develop cancer. Meeting on development and cancer.

Authors:  Offer Gerlitz; Erwin F Wagner; Eduardo Moreno
Journal:  EMBO Rep       Date:  2008-07-18       Impact factor: 8.807

Review 8.  Mechanisms and mechanics of cell competition in epithelia.

Authors:  Jean-Paul Vincent; Alexander G Fletcher; L Alberto Baena-Lopez
Journal:  Nat Rev Mol Cell Biol       Date:  2013-08-14       Impact factor: 94.444

Review 9.  Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics.

Authors:  Cayetano Gonzalez
Journal:  Nat Rev Cancer       Date:  2013-02-07       Impact factor: 60.716

10.  Selection and adaptation during metastatic cancer progression.

Authors:  Christoph A Klein
Journal:  Nature       Date:  2013-09-19       Impact factor: 49.962

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